Sam Alam

University of Cambridge — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

4h-index244citations22works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(13), Peptidase Inhibition and Analysis(9), Chronic Obstructive Pulmonary Disease (COPD) Research(5), Pulmonary Hypertension Research and Treatments(5), Transplantation: Methods and Outcomes(3)

Publications22 total

S63 F alpha-1 antitrypsin polymerises and promotes an exaggerated inflammatory response
Thorax·2013Open Access
P185 Pulmonary infection in PiZZ antitrypsin individuals is associated with increased oxidative and nitrosative stress
Thorax·2013Open Access
Inflammation induced conformational changes in Z alpha-1 antirypsin promotes lung Z-AT cell damage
2013
Cigarette smoke activates ER overload response in Z-AT mice
2013
Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy
EMJ Hepatology·2013· 1 citedOpen Access
S84 Cigarette Smoke Promotes Exaggerated Inflammatory Response in the Presence of Z-AT
Thorax·2012Open Access
S86 Formation of Oxidised Alpha-1 Antitrypsin Induces Inflammatory Response in Human Bronchial Epithelial Cells
Thorax·2012· 1 citedOpen Access
P255 The Effects of Hypoxia on Neutrophil Degranulation
Thorax·2012· 1 citedOpen Access
Oxidized-polymers of Z-AT are associated with exaggerated pulmonary inflammation post lung transplantation
2012
Z antitrypsin polymerization is associated with enhanced pulmonary inflammation
2012
Exaggerated Lung Inflammation In The Presence Of Z Antitrypsin
2012
The Role of Alpha-1 Antitrypsin in Emphysema
InTech eBooks·2012· 1 citedOpen Access
Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A
Journal of Hepatology·2012· 33 cited
S54 Polymers of Z  1-antitrypsin are associated with pulmonary infection post lung transplantation
Thorax·2011Open Access
S51 Reducing intracellular aggregation and improving the secretion of Z alpha-1 antitrypsin
Thorax·2011Open Access
Preventing the consequences of Z alpha-1 accumulation in vivo
2011
Methods in Enzymology
Methods in enzymology on CD-ROM/Methods in enzymology·2011
The Serpinopathies
Methods in enzymology on CD-ROM/Methods in enzymology·2011· 36 cited
S60 Cigarette smoke induced oxidation of  -1 antitrypsin amplifies the pulmonary inflammatory response
Thorax·2010Open Access
S61 Cigarette smoke promotes polymerisation of Z  1-antitrypsin
Thorax·2010Open Access
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Frequent Co-authors

Ravi Mahadeva(20), Sabina Janciauskiene(6), Zhenjun Li(5), Sabina Janciauskiene(4), K. Santhanakrishnan(4), Jicun Wang(3), Edwin R. Chilvers(3), Zhe Li(3), J. Parmar(3), James A. Irving(2), Ugo Ekeowa(2), Didier Belorgey(2), Imran Ul Haq(2), Bibek Gooptu(2), Benoit D. Roussel(2), A. Ordóñez(2), Lucy E. Dalton(2), Stefan J. Marciniak(2), Helen Parfrey(2), Jeffrey Teckman(2)