L Nelles

Galapagos (Belgium) — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index4.1kcitations83works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(44), Enzyme Production and Characterization(19), Blood Coagulation and Thrombosis Mechanisms(17), Blood properties and coagulation(13), Cystic Fibrosis Research Advances(5)

Publications83 total

Discovery of 9-Cyclopropylethynyl-2-((<i>S</i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a</i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial
Journal of Medicinal Chemistry·2020· 42 citedOpen Access
Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators
Frontiers in Pharmacology·2019· 39 citedOpen Access
Identification and Characterization of Novel CFTR Potentiators
Frontiers in Pharmacology·2018· 41 citedOpen Access
Discovery of<i>N</i>-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4<i>H</i>-thieno[2,3-<i>c</i>]pyran-2-yl)-l<i>H</i>-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
WS06.3 Evaluation of novel corrector–potentiator combinations for treating cystic fibrosis in various assays
Journal of Cystic Fibrosis·2015Open Access
Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic
Journal of Medicinal Chemistry·2014· 107 citedOpen Access
Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634
Journal of Medicinal Chemistry·2014· 116 citedOpen Access
Novel corrector-potentiator combinations for treating Cystic Fibrosis
2014
Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases
The Journal of Immunology·2013· 226 citedOpen Access
222 PHARMACOLOGICAL INVESTIGATION OF THE ROLE OF AGGRECANASES IN HUMAN CARTILAGE DEGRADATION
Osteoarthritis and Cartilage·2009
Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap
The International Journal of Developmental Biology·2009· 4 citedOpen Access
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
Development·2007· 42 citedOpen Access
Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
Oncogene·2007· 472 cited
Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat–Wilson syndrome
Human Molecular Genetics·2007· 99 citedOpen Access
Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein
Genes to Cells·2005· 16 cited
Cloning and expression of the cyclophilin Bet v 7, and analysis of immunological cross-reactivity among the cyclophilin A family
Molecular Immunology·2005· 28 cited
Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1☆
Genomics·2003· 39 cited
Interaction between Smad-interacting Protein-1 and the Corepressor C-terminal Binding Protein Is Dispensable for Transcriptional Repression of E-cadherin
Journal of Biological Chemistry·2003· 104 citedOpen Access
Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome
The American Journal of Human Genetics·2003· 307 citedOpen Access
Generation of the floxed allele of the SIP1 (<i>Smad‐interacting protein 1</i>) gene for Cre‐mediated conditional knockout in the mouse
genesis·2002· 110 citedOpen Access
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Frequent Co-authors

D Collen(17), Danny Huylebroeck(12), H.R. Lijnen(8), Désiré Collen(8), Kristin Verschueren(7), Tom Van de Putte(7), Thierry Christophe(6), B. Van Hoef(6), F. Bulens(6), Katja Conrath(5), Reginald Brys(5), William E. Holmes(5), Leo A. van Grunsven(5), H.R. Lijnen(5), Jacques Remacle(4), Gunther Wuytens(4), Stephen R. Fletcher(4), Clara Collart(3), Ellen M. van der Aar(3), Philippe Clément-Lacroix(3)