T. D. Southgate

GlaxoSmithKline (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index990citations19works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Virus-based gene therapy research(14), Cytomegalovirus and herpesvirus research(6), RNA Interference and Gene Delivery(5), Herpesvirus Infections and Treatments(4), CAR-T cell therapy research(3)

Publications19 total

36P In-vitro tonic signalling profiling of CAR-T cells generated to support pre-clinical studies for solid tumour targets
Annals of Oncology·2021
O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy
British Medical Bulletin·2008· 136 citedOpen Access
Adenoviruses Encoding HPRT Correct the Biochemical Abnormalities Fully Only in HPRT-Deficient Human Cell Lines: Importance of Species Differences
Kluwer Academic Publishers eBooks·2006· 3 cited
Diffusible VP22–E2 Protein Kills Bystander Cells and Offers a Route for Cervical Cancer Gene Therapy
Human Gene Therapy·2006· 13 citedOpen Access
Human monocytes expressing a CEA-specific chimeric CD64 receptor specifically target CEA-expressing tumour cells in vitro and in vivo
Gene Therapy·2006· 63 cited
Diffusible VP22-E2 Protein Kills Bystander Cells and Offers a Route for Cervical Cancer Gene Therapy
Human Gene Therapy·2005· 3 cited
Long-Term Transgene Expression within the Anterior Pituitary Gland in Situ: Impact on Circulating Hormone Levels, Cellular and Antibody-Mediated Immune Responses
Endocrinology·2001· 18 cited
Cell Type Specific and Inducible Transgenesis in the Anterior Pituitary Gland
Endocrine updates·2001· 1 cited
Long-Term Transgene Expression within the Anterior Pituitary Gland<i>in Situ</i>: Impact on Circulating Hormone Levels, Cellular and Antibody-Mediated Immune Responses<sup>1</sup>
Endocrinology·2001· 28 citedOpen Access
Cell type specific and inducible transient transgenics in the anterior pituitary gland
2001
Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries
Endocrinology·2000· 17 cited
Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries*
Endocrinology·2000· 68 citedOpen Access
Adenovirus-mediated gene transfer to human lens epithelial cells in organ culture
Journal of Cataract & Refractive Surgery·2000· 7 cited
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK
Gene Therapy·2000· 48 cited
Adenovirus-Mediated Herpes Simplex Virus Type-1 Thymidine Kinase Gene Therapy Suppresses Oestrogen-Induced Pituitary Prolactinomas*
The Journal of Clinical Endocrinology & Metabolism·2000· 58 citedOpen Access
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
Nature Medicine·1999· 314 cited
Erratum for Cartmell et al., Interleukin-1 Mediates a Rapid Inflammatory Response after Injection of Adenoviral Vectors into the Brain
Journal of Neuroscience·1999Open Access
Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.
Journal of General Virology·1999· 107 cited
Interleukin-1 Mediates a Rapid Inflammatory Response After Injection of Adenoviral Vectors into the Brain
Journal of Neuroscience·1999· 106 citedOpen Access

Frequent Co-authors

María G. Castro(11), Pedro R. Löwenstein(10), Ricardo A. Dewey(4), Daniel Stone(4), David Klatzmann(4), Joseph R. Smith-Arica(4), Tricia C. Maleniak(3), Graham Morrissey(2), Christine M. Cowsill(2), Federico Bolognani(2), David E. Gilham(2), Adrián E. Morelli(2), Adriana T. Larregina(2), Giamal N. Luheshi(2), S. Windeatt(2), Marcelo J. Perone(2), Ian D. Morris(2), Judith C. Williams(2), Kate Mulryan(2), Lez J. Fairbairn(2)