Kaneyoshi Kato

Takeda (Japan) — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index996citations23works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(5), Eicosanoids and Hypertension Pharmacology(4), Alzheimer's disease research and treatments(3), Receptor Mechanisms and Signaling(3), Synthetic Organic Chemistry Methods(3)

Publications23 total

Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines
Journal of Medicinal Chemistry·2012· 31 citedOpen Access
Discovery, synthesis, and structure–activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists
Bioorganic & Medicinal Chemistry·2011· 10 citedOpen Access
Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats
Brain Research·2010· 21 cited
A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
Journal of Neuroscience·2010· 127 citedOpen Access
From peptide to non-peptide: The design of LHRH antagonist mimetics
Kluwer Academic Publishers eBooks·2006
P4-403 TAK-070, a non-peptidic bace inhibitor, decreases levels of soluble and insoluble amyloid beta 40/42 as well as formation of amyloid plaques in TG2576 mice
Neurobiology of Aging·2004· 1 cited
T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist
European Journal of Pharmacology·2002· 201 citedOpen Access
Effects of thromboxane A2 synthase inhibitors (CV-4151 and ozagrel), aspirin, and ticlopidine on the thrombosis caused by endothelial cell injury
Thrombosis Research·1995· 12 cited
A Novel Route to Pyrimidine Nucleosides via Intramolecular Couplings of Bases with 2′-Deoxyribosides: Quick and Stereospecific...but with a 'Twist'
Synthesis·1994· 23 cited
Hydrozirconation / transmetalation / alkylation: direct one-pot conversion of 1-alkynes to E-1,2-disubstituted alkenes
Tetrahedron Letters·1991· 27 cited
Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation
Journal of Medicinal Chemistry·1989· 40 citedOpen Access
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids
Journal of Medicinal Chemistry·1988· 246 cited
2-O-ALKYLASCORBIC ACID DERIVATIVES WITH SCAVENGING ACTIVITY AGAINST ACTIVE OXYGEN SPECIES (AOS)
Journal of Pharmacobio-Dynamics·1987
THROMBOXANE SYNTHETASE INHIBITORS (TXSI). SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF CV-4151
Journal of Pharmacobio-Dynamics·1985
Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of .omega.-pyridylalkenoic acids
Journal of Medicinal Chemistry·1985· 99 citedOpen Access
STUDIES ON THE SYNTHESIS OF 5-LIPOXYGENASE INHIBITORS
Journal of Pharmacobio-Dynamics·1984
Enzyme immunoassay of thromboxane B2
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism·1983· 22 cited
Renal effects of pinane-thromboxane A2 and indomethacin in saline volume-expanded spontaneously hypertensive rats
European Journal of Pharmacology·1982· 9 cited
Quinones. Part 2. General synthetic routes to quinone derivatives with modified polyprenyl side chains and the inhibitory effects of these quinones on the generation of the slow reacting substance of anaphylaxis (SRS-A)
Journal of the Chemical Society Perkin Transactions 1·1982· 18 cited
Role of renal thromboxane A2 and prostaglandins in the pathogenesis of hypertension in spontaneously hypertensive rats
The Japanese Journal of Pharmacology·1982Open Access
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Frequent Co-authors

Shinji Terao(10), Jun Terauchi(5), Mitsuru Shiraishi(5), Shigenori Ohkawa(4), Zen‐ichi Terashita(4), Kohei Nishikawa(4), Shiro Takekawa(3), Asano Asami(3), Yuji Ishihara(3), Koki Kato(3), Nobuhiro Suzuki(3), Hiroaki Fukumoto(3), Hideki Takahashi(3), Masaomi Miyamoto(3), Norio Shimamoto(2), Minoru Hirata(2), Mitsuhiro Hirode(2), Masumi Sagayama(2), Ryouta Maeda(2), Kazuko Hirai(2)