D E Brough

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.2kcitations25works3.02yr avg
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Research Topics

Virus-based gene therapy research(16), RNA Interference and Gene Delivery(6), CAR-T cell therapy research(6), Viral Infectious Diseases and Gene Expression in Insects(6), Animal Disease Management and Epidemiology(4)

Publications25 total

Biomimetic Digital Twins and Multiomics
Journal of Molecular Diagnostics·2025· 1 cited
The Application of Knowledge Engineering via the Use of a Biomimetic Digital Twin Ecosystem, Phenotype-Driven Variant Analysis, and Exome Sequencing to Understand the Molecular Mechanisms of Disease
Journal of Molecular Diagnostics·2024· 5 citedOpen Access
Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle
Transboundary and Emerging Diseases·2017· 21 citedOpen Access
Human adenovirus-vectored foot-and-mouth disease vaccines: establishment of a vaccine product profile through in vitro testing.
PubMed·2012· 23 cited
Analysis of Adenovirus -Vectored Foot-and-Mouth Disease Virus Transgene Expression in Bovine Kidney Cells by Confocal, Electron, and Immuno-Electron Microscopy
Microscopy and Microanalysis·2011Open Access
Selective atonal gene delivery improves balance function in a mouse model of vestibular disease
Gene Therapy·2011· 83 citedOpen Access
Intracellular Localization of Foot-and-Mouth Disease Virus Transgene Expression in vivo and in vitro After Infection with Adenovirus Vaccine Constructs
Microscopy and Microanalysis·2009
Adenovirus-Mediated Expression of Interferon-α Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus
Viral Immunology·2009· 35 cited
Prolonged Gene Expression Using an Alternative Serotype Vector With RGD
Investigative Ophthalmology & Visual Science·2009
Alternate Serotype Adenovector Gives Long-Term Expression in the Eye
Investigative Ophthalmology & Visual Science·2007
MMP–9 Modulates Pigment Epithelium–Derived Factor Control of Angiogenesis via Proteolysis
Investigative Ophthalmology & Visual Science·2006
All Trans–Retinoic Acid Regulation of Transgene Expression in the Eye
Investigative Ophthalmology & Visual Science·2006
Comprehensive characterization of the 293-ORF6 cell line.
PubMed·2006· 12 cited
Activation of Pigment Epithelium–Derived Factor (PEDF) From Silenced Adenovector Genomes––Possible Therapeutic Approach for Prolonged Gene Expression Following Single Intravitreal Administration of AdPEDF
Investigative Ophthalmology & Visual Science·2005
Activation of Gene Expression from Silenced Adenovector Genomes
Investigative Ophthalmology & Visual Science·2004· 2 cited
Adenoviral Gene Delivery for the Treatment of Ocular Diseases
Investigative Ophthalmology & Visual Science·2003
Ocular Sublocalization and Pharmacokinetics of Expression of Pigment Epithelium-Derived Factor in Murine Eyes Following Adenovirus-Based Intravitreous Gene Delivery
Investigative Ophthalmology & Visual Science·2003· 1 cited
Adenoviral Vector Genome Evaluation after Intravitreal Administration
Investigative Ophthalmology & Visual Science·2003
Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo
Journal of Virology·1997· 93 citedOpen Access
Construction of an adenovirus type 7a E1A- vector
Journal of Virology·1997· 42 citedOpen Access
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Frequent Co-authors

C. Richter King(8), Chih‐Wei Hsu(7), Melissa Hamilton(7), Alena Lizonová(5), Duncan McVey(5), Lisa L. Wei(5), David A. Brake(4), John G. Neilan(4), L.L. Wei(4), Imre Kovesdi(3), Marvin J. Grubman(3), J.A. Barrera(3), T. G. Burrage(3), Bryan T. Butman(3), G M Lee(2), V Kulesa(2), Daniel F. Klessig(2), Damodar Ettyreddy(2), Clare Purcell(2), Christopher Schutta(2)