D. Euan MacIntyre

Center for Advancing Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index10.3kcitations182works1.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(27), Antiplatelet Therapy and Cardiovascular Diseases(23), Inflammatory mediators and NSAID effects(21), Regulation of Appetite and Obesity(20), Neuropeptides and Animal Physiology(20)

Publications182 total

Artificial Intelligence-Assisted Matching of Human Postmortem Donors to Ocular Research Projects
Advances in experimental medicine and biology·2025· 1 cited
Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels
Acta Physiologica·2019· 25 citedOpen Access
NMR Metabolic Phenotyping in Clinical Studies
Elsevier eBooks·2016· 1 cited
Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator
Anesthesiology·2015· 30 cited
GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells
Advances in experimental medicine and biology·2015· 8 cited
GAL‐160 increases CO <sub>2</sub> chemosensitivity and reverses opioid‐induced respiratory depression in rats (1092.14)
The FASEB Journal·2014
The Effects Of Doxapram Enantiomers On The Hypoxic Ventilatory Response In Adult Rats
2012
Reversal Of Opioid-Induced Respiratory Depression By GAL-021, A Novel Respiratory Stimulant
2012· 2 cited
GAL‐021 –induced respiratory stimulation is associated with increases in carotid sinus nerve and phrenic motoneuron activity in rats
The FASEB Journal·2012· 5 cited
GAL‐021, a novel respiratory stimulant, attenuates opioid–induced respiratory depression without compromising analgesia
The FASEB Journal·2012· 6 cited
Comparison of the respiratory effects of GAL‐021 in BK α subunit knockout ( <i>Slo1−/ −</i> ) and wild‐type mice
The FASEB Journal·2012
Reversal of opioid –induced respiratory depression by the (+)‐ enantiomer, GAL‐054, but not the (−)‐enantiomer, GAL‐053, of doxapram
The FASEB Journal·2012· 4 cited
Enantiomeric separation of doxapram reveals a superior respiratory stimulant, GAL‐054
The FASEB Journal·2012· 3 cited
GAL‐021 acts as a novel respiratory stimulant in non‐human primates
The FASEB Journal·2012· 4 cited
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
Bioorganic & Medicinal Chemistry Letters·2011· 16 citedOpen Access
CCDC 780119: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
European Journal of Pharmacology·2010· 71 cited
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia
Bioorganic & Medicinal Chemistry Letters·2010· 72 citedOpen Access
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker
Journal of Pharmacology and Experimental Therapeutics·2010· 97 cited
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Frequent Co-authors

Joseph M. Metzger(10), Margaret A. Cascieri(10), Lex H.T. Van der Ploeg(8), Alison M. Strack(7), William J. Martin(7), Gary J. Hom(7), Xiao-Ming Guan(6), Erin McGowan(6), Hong Yu(5), Catherine Abbadie(5), Michael J. Forrest(5), Ralph A. Stearns(5), F.D. Tattersall(5), Wayne Rycroft(5), Richard Hargreaves(5), Sharon Sadowski(5), William P. Feeney(5), Matthew J. Wyvratt(5), Ramon E. Camacho(4), Lauren P. Shearman(4)