Knud H. Nierhaus

Charité - Universitätsmedizin Berlin — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

65h-index11.9kcitations254works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(227), RNA modifications and cancer(163), Bacterial Genetics and Biotechnology(63), RNA Research and Splicing(39), Peptidase Inhibition and Analysis(28)

Publications254 total

First biochemical evidence for evolutionary conservation of ribosomal proteins at the peptidyl transferase center in all kingdoms of life: ribosomal protein bL12 assists catalysis in E. coli 70S ribosomes
HAL (Le Centre pour la Communication Scientifique Directe)·2021
New insights into the mechanism of peptide bond formation: the eukaryote-specific large subunit ribosomal protein eL42 contributes to catalysis at the elongation step of translation
HAL (Le Centre pour la Communication Scientifique Directe)·2021
Targeting the human large subunit ribosomal protein eL42 and its interaction with the tumor suppressor p53 for cancer therapy
HAL (Le Centre pour la Communication Scientifique Directe)·2021
Reconstitution of 30S ribosomal subunits in vitro using ribosome biogenesis factors
RNA·2018· 37 citedOpen Access
Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution
Molecular Cell·2018· 65 citedOpen Access
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process
WORLD SCIENTIFIC eBooks·2018· 19 cited
Direct Visualization of A-, P-, and E-Site Transfer RNAs in the <i>Escherichia coli</i> Ribosome
WORLD SCIENTIFIC eBooks·2018
Translation and folding of single proteins in real time
Proceedings of the National Academy of Sciences·2017· 93 citedOpen Access
The Termination Phase in Protein Synthesis is not Obligatorily Followed by the RRF/EF-G-Dependent Recycling Phase
Journal of Molecular Biology·2016· 12 cited
Ribosome Assembly as Antimicrobial Target
Antibiotics·2016· 20 citedOpen Access
70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria
Proceedings of the National Academy of Sciences·2016· 91 citedOpen Access
Following Translation and Folding of Individual Proteins by Single Ribosomes in Real-Time using Optical Tweezers
Biophysical Journal·2016Open Access
Response to the Formal Letter of Z. Chrzanowska-Lightowlers and R. N. Lightowlers Regarding Our Article “Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria”
PLoS Genetics·2015· 8 citedOpen Access
Ribosomal Proteins: Role in Ribosomal Functions
Encyclopedia of Life Sciences·2015· 27 cited
Outwitting EF-Tu and the ribosome: translation with d-amino acids
Nucleic Acids Research·2015· 59 citedOpen Access
The mechanics of ribosomal translocation
Biochimie·2014· 18 cited
Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria
PLoS Genetics·2014· 74 citedOpen Access
Mg <sup>2+</sup> , K <sup>+</sup> , and the Ribosome
Journal of Bacteriology·2014· 118 citedOpen Access
EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon–anticodon duplex
Nature Structural & Molecular Biology·2014· 44 cited
Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement
Cell·2014· 146 citedOpen Access
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Frequent Co-authors

Daniel N. Wilson(8), C.M.T. Spahn(6), Rajendra K. Agrawal(6), Paola Fucini(6), Joachim Frank(5), Carol V. Robinson(4), Pawel A. Penczek(4), Robert A. Grassucci(4), Witold Szaflarski(4), Markus Pech(4), Hiroshi Yamamoto(4), Sean R. Connell(3), Ferdinand Dohme(3), Christopher M. Dobson(3), Francisco J. Triana‐Alonso(3), Thorsten Mielke(3), Gregor Blaha(2), Ulrich Stelzl(2), Yan Qin(2), Nils Burkhardt(2)