James E. Zadina

Southeast Louisiana Veterans Health Care System — United States

Neuroscience · Life Sciences

44h-index7.0kcitations133works3.52yr avg
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Research Topics

Neuropeptides and Animal Physiology(99), Pain Mechanisms and Treatments(44), Receptor Mechanisms and Signaling(37), Macrophage Migration Inhibitory Factor(30), Neuroendocrine regulation and behavior(16)

Publications133 total

Cyclic Glycopeptide Analogs of Endomorphin-1 Provide Highly Effective Antinociception in Male and Female Mice
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Comparison of Morphine and Endomorphin Analog ZH853 for Tolerance and Immunomodulation in a Rat Model of Neuropathic Pain
Journal of Pain·2024· 4 citedOpen Access
Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking
Neuropharmacology·2023· 5 citedOpen Access
Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder
Journal of Pharmacology and Experimental Therapeutics·2019· 10 citedOpen Access
Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization
Journal of Neuroinflammation·2019· 46 citedOpen Access
Novel Endomorphin Analogs Are More Potent and Longer-Lasting Analgesics in Neuropathic, Inflammatory, Postoperative, and Visceral Pain Relative to Morphine
Journal of Pain·2017· 40 cited
Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine
Neuropharmacology·2015· 91 cited
Viral Vectors Encoding Endomorphins and Serine Histogranin Attenuate Neuropathic Pain Symptoms after Spinal Cord Injury in Rats
Molecular Pain·2015· 22 citedOpen Access
Pleiotropic Opioid Regulation of Spinal Endomorphin 2 Release and Its Adaptations to Opioid Withdrawal Are Sexually Dimorphic
Journal of Pharmacology and Experimental Therapeutics·2011· 16 citedOpen Access
Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models
Progress in Neuro-Psychopharmacology and Biological Psychiatry·2010· 239 cited
Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides
Neuropeptides·2010· 50 citedOpen Access
A Novel Method to Quantify Histochemical Changes Throughout the Mediolateral Axis of the Substantia Gelatinosa After Spared Nerve Injury: Characterization with TRPV1 and Substance P
Journal of Pain·2010· 29 citedOpen Access
Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression
Molecular and Cellular Neuroscience·2009· 35 cited
Cathepsin L Participates in the Production of the Dynorphin Opioid Peptide Neurotransmitter
The FASEB Journal·2009
Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus
Brain Research·2008· 74 citedOpen Access
Colocalization and shared distribution of endomorphins with substance P, calcitonin gene‐related peptide, γ‐aminobutyric acid, and the mu opioid receptor
The Journal of Comparative Neurology·2007· 32 cited
Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine
Brain Research·2005· 23 cited
Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells
Brain Research·2004· 37 cited
Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice
Neuroscience Letters·2004· 13 cited
Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells
Experimental Brain Research·2004· 18 citedOpen Access
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Frequent Co-authors

Abba J. Kastin(33), Laszlo Hackler(7), Lin-Jun Ge(6), William A. Banks(6), Sheryl Martin‐Schild(5), Arnold A. Gerall(4), David H. Coy(4), Lawrence M. Maness(3), Shinobu Sakurada(3), Tsutomu Fujimura(3), Kimie Murayama(3), Tsukasa Sakurada(3), Hunter C. Champion(3), Philip J. Kadowitz(3), Laura M. Harrison(2), Abba J. Kastin(2), Joseph T. Weber(2), Robert N. McLay(2), Xing Zhang(2), Marc A. Czapla(2)