Witold Neugebauer

Université de Sherbrooke — Canada

Medicine · Health Sciences

31h-index2.3kcitations83works0.02yr avg
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Research Topics

Coagulation, Bradykinin, Polyphosphates, and Angioedema(20), Chemical Synthesis and Analysis(18), Neuropeptides and Animal Physiology(13), Peptidase Inhibition and Analysis(13), Receptor Mechanisms and Signaling(12)

Publications83 total

Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells
Journal of Cellular Physiology·2018· 27 cited
Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer
Oncotarget·2018· 24 citedOpen Access
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4
Journal of Medicinal Chemistry·2017· 11 citedOpen Access
Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors
ChemMedChem·2016· 14 cited
Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions
Biological Chemistry·2015· 7 cited
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation
Oncotarget·2015· 35 citedOpen Access
Regulation of<scp>μ</scp>and<scp>δ</scp>opioid receptor functions: involvement of cyclin‐dependent kinase 5
British Journal of Pharmacology·2015· 14 citedOpen Access
Hintze, Otto (1861–1940)
Elsevier eBooks·2015
Design, Synthesis, and Structure–Activity Relationship Studies of a Potent PACE4 Inhibitor
Journal of Medicinal Chemistry·2013· 31 citedOpen Access
Dual kinin B1 and B2 receptor activation provides enhanced blood–brain barrier permeability and anticancer drug delivery into brain tumors
Cancer Biology & Therapy·2013· 35 citedOpen Access
Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
Biological Chemistry·2013· 18 cited
Synthesis of a Double Marker Synthon (NMR and Fluorescent) for Peptide Labeling
2013
The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
Journal of Medicinal Chemistry·2012· 48 citedOpen Access
Correction: Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat Model
PLoS ONE·2012Open Access
Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat Model
PLoS ONE·2012· 49 citedOpen Access
Impact of H‐aggregation on activatable MMP‐2‐specific probes for optical imaging
Contrast Media & Molecular Imaging·2012· 5 cited
Evaluation of Deuterium Labeled and Unlabeled Bis-methyl Glutathione Combined with Nanoliquid Chromatography−Mass Spectrometry to Screen and Characterize Reactive Drug Metabolites
Chemical Research in Toxicology·2011· 10 cited
New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging
Journal of Medicinal Chemistry·2009· 48 cited
C-Terminal Amidation On Aryl Hydrazine Resin
Advances in experimental medicine and biology·2009
Design, Synthesis and Pharmacological Characterization of Fluorescein-Derived Endothelin Antagonists Bq-123 And Bq-788
Advances in experimental medicine and biology·2009· 3 cited
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Frequent Co-authors

Gordon E. Willick(12), J. F. Whitfield(7), Jérôme Côté(7), Martin Savard(7), Fernand Gobeil(7), Lyne Gagnon(5), Ryszard Brzeziński(5), Veronica Bovenzi(5), Céléna Dubuc(5), Christine Levesque(5), Anna Kwiatkowska(5), Frédéric Couture(5), Roxane Desjardins(5), Robert Day(5), D. Regoli(5), Balu Chakravarthy(4), Jon P. Durkin(4), Wing L. Sung(4), Pedro D’Orléans-Juste(4), Emanuel Escher(4)