Kirk R. Manogue

Feinstein Institute for Medical Research — United States

Immunology and Microbiology · Life Sciences

31h-index14.9kcitations39works0.02yr avg
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Research Topics

Immune Response and Inflammation(9), Macrophage Migration Inhibitory Factor(5), Adipokines, Inflammation, and Metabolic Diseases(4), Animal Behavior and Reproduction(3), Nutrition and Health in Aging(3)

Publications39 total

CCDC 2195262: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates
Nature Communications·2022· 15 citedOpen Access
CCDC 2195263: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
The Pathological Role of Cachectin/ Tumor Necrosis Factor in Septic Shock and Chronic Disease: In vivo Evidence
2015· 1 cited
Inhibition of MIF Bioactivity by Rational Design of Pharmacological Inhibitors of MIF Tautomerase Activity
Journal of Medicinal Chemistry·2002· 125 citedOpen Access
Characterization of a Novel Hemoglobin-Glutathione Adduct That Is Elevated in Diabetic Patients
Molecular Medicine·2001· 37 citedOpen Access
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Science·1999· 3.4k cited
Induction of the Chemokine β Peptides, MIP-1α and MIP-1β, by Lipopolysaccharide Is Differentially Regulated by Immunomodulatory Cytokines γ-IFN, IL-10, IL-4, and TGF-β
Molecular Medicine·1998· 66 citedOpen Access
Other approaches
Nature·1995· 18 cited
An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
Molecular Medicine·1995· 118 citedOpen Access
Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention
Molecular Medicine·1995· 43 citedOpen Access
Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure
The Lancet·1994· 372 cited
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
Nature·1993· 991 cited
Cachectin/TNF-mediated lactate production in cultured myocytes is linked to activation of a futile substrate cycle
Cytokine·1993· 62 cited
Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines
The Journal of Immunology·1993· 250 cited
Human decidua: a source of cachectin-tumor necrosis factor
European Journal of Obstetrics & Gynecology and Reproductive Biology·1991· 89 cited
Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78
The Journal of Immunology·1991· 46 cited
Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.
Journal of Clinical Investigation·1990· 231 citedOpen Access
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
The Lancet·1990· 865 cited
Processing of newly synthesized cachectin/tumor necrosis factor in endotoxin-stimulated macrophages
Biochemistry·1990· 84 cited
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Frequent Co-authors

Anthony Cerami(18), Kevin J. Tracey(10), Barbara Sherry(8), Anthony Cerami(5), Yousef Al‐Abed(5), Yuman Fong(4), Richard Bucala(4), Sonya VanPatten(4), David Hesse(3), George Kuo(3), H. R. Michie(3), David R. Spriggs(3), Helen Vlassara(3), Christine N. Metz(3), Michael Bukrinsky(3), Ahmad S. Altiti(3), Umair Ahmed(3), Pui Yan Chiu(3), Ibrahim T. Mughrabi(3), Bayan Al Jabari(3)