Verne Schirch

Virginia Commonwealth University — United States

Materials Science · Physical Sciences

38h-index4.0kcitations114works0.02yr avg
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Research Topics

Enzyme Structure and Function(79), Amino Acid Enzymes and Metabolism(66), Metabolism and Genetic Disorders(37), Biochemical and Molecular Research(34), Folate and B Vitamins Research(22)

Publications114 total

Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency
Frontiers in Pharmacology·2019· 11 citedOpen Access
Inactive mutants of human pyridoxine 5′‐phosphate oxidase: a possible role for a noncatalytic pyridoxal 5′‐phosphate tight binding site
FEBS Open Bio·2016· 16 citedOpen Access
Molecular basis of E. coli l-threonine aldolase catalytic inactivation at low pH
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2015· 8 citedOpen Access
Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction
BioMed Research International·2013· 18 citedOpen Access
Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase
PLoS ONE·2012· 58 citedOpen Access
Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition
PLoS ONE·2012· 35 citedOpen Access
Molecular Defects of Vitamin B6 Metabolism Associated with Neonatal Epileptic Encephalopathy
InTech eBooks·2012· 7 citedOpen Access
Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder
Journal of Biological Chemistry·2009· 49 citedOpen Access
Crystal Structure of Human Pyridoxine 5'-Phosphate Oxidase R229W Mutant
2009
Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase
Biochemical and Biophysical Research Communications·2009· 28 cited
Crystal structure of D235A mutant of human pyridoxal kinase
2008
Crystal Structure of human pyridoxal kinase: Structural basis of M<sup>+</sup> and M<sup>2+</sup> activation
Protein Science·2007· 47 cited
Human Pyridoxal Kinase
2007
Crystal Structure of Pyridoxal Kinase from the <i>Escherichia coli pdxK</i> Gene: Implications for the Classification of Pyridoxal Kinases
Journal of Bacteriology·2006· 59 citedOpen Access
Crystal Structure of Pyridoxal Kinase from the Escherichia coli PdxK gene complexed with pyridoxal at 3.2 A resolution
2006
Serine hydroxymethyltransferase revisited
Current Opinion in Chemical Biology·2005· 153 cited
Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations
Archives of Biochemistry and Biophysics·2005· 27 cited
Structure of<i>Escherichia coli</i>pyridoxine 5′-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme
Acta Crystallographica Section D Biological Crystallography·2005· 12 cited
X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form
2004
Crystal Structure of the PdxY Protein from <i>Escherichia coli</i>
Journal of Bacteriology·2004· 43 citedOpen Access
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Frequent Co-authors

Martino L. di Salvo(15), Martin K. Safo(12), Faik N. Musayev(11), Patrick J. Stover(7), Francesco Bossa(6), Sebastiana Angelaccio(5), William B. Strong(4), Roberto Contestabile(4), Stefano Pascarella(4), Douglas Schirch(4), Sam Hopkins(3), Enrique Villar(3), J.N. Scarsdale(3), Galina Kazanina(3), H.T. Wright(3), Tzu‐Ping Ko(3), Tzu‐Fun Fu(3), K Shostak(3), Sharyn Hunt(3), Mohini S. Ghatge(3)