Paula Bertram

Washington University in St. Louis — United States

Immunology and Microbiology · Life Sciences

20h-index3.1kcitations39works0.02yr avg
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Research Topics

Complement system in diseases(14), Blood groups and transfusion(5), PI3K/AKT/mTOR signaling in cancer(4), Poxvirus research and outbreaks(4), Mitochondrial Function and Pathology(3)

Publications38 total

82 Using the C3 gain-of-function mouse model of aHUS as a complement therapeutic testbed to enable precision medicine for complement mediated atypical haemolytic uraemic syndrome
Immunobiology·2023
A Multimodality Approach to Assessing Factor I Genetic Variants in Atypical Hemolytic Uremic Syndrome
Kidney International Reports·2019· 18 citedOpen Access
<scp>TREX</scp> 1 is expressed by microglia in normal human brain and increases in regions affected by ischemia
Brain Pathology·2018· 19 citedOpen Access
Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse
American Journal of Reproductive Immunology·2018· 5 citedOpen Access
A C3(H20) recycling pathway is a component of the intracellular complement system
Journal of Clinical Investigation·2017· 109 citedOpen Access
Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode
The EMBO Journal·2016· 105 citedOpen Access
Anti-Mouse Properdin TSR 5/6 Monoclonal Antibodies Block Complement Alternative Pathway-dependent Pathogenesis
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·2015· 16 citedOpen Access
Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS)
Molecular Immunology·2014· 6 citedOpen Access
Complement Regulatory Protein CD46 Protects against Choroidal Neovascularization in Mice
American Journal Of Pathology·2014· 43 citedOpen Access
Ure2p, and Phosphatases Tripartite Regulation of Gln3p by TOR, TRANSDUCTION: MECHANISMS OF SIGNAL
2014
between Gln3p and the Nuclear Import Phosphorylation Regulates the Interaction TRANSDUCTION: MECHANISMS OF SIGNAL
2014
Autoantibodies to CD59, CD55, CD46 and CD35 are not associated with aHUS
Molecular Immunology·2014· 1 cited
Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation
Immunity·2013· 553 citedOpen Access
Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation
Proceedings of the National Academy of Sciences·2013· 48 citedOpen Access
Cleavage of intracellular C3 into C3a and C3b by cathepsin L is required for human TH1 induction
Immunobiology·2012· 3 cited
In vivo dissection of the contribution of fB, fD and properdin to alternative pathway activation on membranes
Immunobiology·2012
MCP (CD46) autoantibodies are associated with atypical hemolytic uremic syndrome
Immunobiology·2012
Targeted deep sequencing of the complement system in complementopathies
Immunobiology·2012
Ectromelia Virus Inhibitor of Complement Enzymes Protects Intracellular Mature Virus and Infected Cells from Mouse Complement
Journal of Virology·2010· 17 citedOpen Access
Smallpox Inhibitor of Complement Enzymes (SPICE): Dissecting Functional Sites and Abrogating Activity
The Journal of Immunology·2009· 32 citedOpen Access
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Frequent Co-authors

John P. Atkinson(19), M. Kathryn Liszewski(11), Xiao-Feng Zheng(11), Marilyn K. Leung(8), John Carvalho(6), Ting‐Fung Chan(5), Richard E. Hauhart(5), Dennis E. Hourcade(5), David Kavanagh(4), Wandong Ai(4), Kevin J. Marchbank(4), Chenbo Zeng(3), R. Mark L. Buller(3), Xiaobo Wu(3), Michael Triebwasser(3), Martin Kolev(2), Claudia Kemper(2), Joanna C. Jen(2), Rula A. Hajj‐Ali(2), Parul H. Kothari(2)