Per‐Olof Hasselgren

Beth Israel Deaconess Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index5.4kcitations100works0.02yr avg
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Research Topics

Muscle Physiology and Disorders(26), Muscle metabolism and nutrition(22), Exercise and Physiological Responses(21), Ubiquitin and proteasome pathways(11), Immune Response and Inflammation(10)

Publications100 total

Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration
Diabetes·2014· 24 citedOpen Access
C/EBPβ regulates dexamethasone‐induced muscle cell atrophy and expression of atrogin‐1 and MuRF1
Journal of Cellular Biochemistry·2011· 33 citedOpen Access
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss
Muscle & Nerve·2011· 50 cited
Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A<sub>2</sub>-dependent mechanism
American Journal of Physiology-Cell Physiology·2010· 26 cited
The NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>κ</mml:mi></mml:math>B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis
Mediators of Inflammation·2008· 61 citedOpen Access
The NF‐<i>κ</i>B Inhibitor Curcumin Blocks Sepsis‐Induced Muscle Proteolysis
Mediators of Inflammation·2008· 9 citedOpen Access
Transcription Factors and Nuclear Cofactors in Muscle Wasting
Intensive Care Medicine·2007· 5 cited
Role of glucocorticoids in the molecular regulation of muscle wasting
Critical Care Medicine·2007· 111 cited
Ubiquitination, phosphorylation, and acetylation—triple threat in muscle wasting
Journal of Cellular Physiology·2007· 55 citedOpen Access
Probiotics potentiate IL-6 production in IL-1β-treated Caco-2 cells through a heat shock-dependent mechanism
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2007· 38 cited
Transcription Factors and Nuclear Cofactors in Muscle Wasting
Yearbook of intensive care and emergency medicine·2007· 3 cited
The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism
International Journal of Molecular Medicine·2006· 4 citedOpen Access
Degradation of C/EBPβ in cultured myotubes is calpain‐dependent
Journal of Cellular Physiology·2006· 27 cited
Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2006· 134 cited
Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPβ in cultured myotubes
Journal of Cellular Biochemistry·2005· 47 cited
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cell·2004· 1.3k citedOpen Access
Treatment of cultured myotubes with the calcium ionophore A23187 increases proteasome activity via a CaMK II-caspase-calpain–dependent mechanism
Surgery·2004· 32 cited
Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis
American Journal of Physiology-Endocrinology and Metabolism·2003· 35 cited
IL-1β stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-κB
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2003· 120 cited
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle
The International Journal of Biochemistry & Cell Biology·2003· 214 cited
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Frequent Co-authors

Josef E. Fischer(12), Curtis J. Wray(12), Michael J. Menconi(7), Bruce W. Robb(7), Dan Hershko(6), Eric S. Hungness(6), Xiaoyan Sun(5), Timothy A. Pritts(5), Greg Tiao(4), J. Howard James(4), Vitaliy Poylin(4), Victoria Petkova(4), Wei Wei(4), Joshua M.V. Mammen(3), Marianne Hall-Angerås(3), Ulf Angerås(3), Darryl T. Hiyama(3), Moin U. Fareed(3), Gyu Gang(3), Guangju Luo(3)