Dorothy Tuan

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index4.1kcitations50works0.02yr avg
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Research Topics

RNA modifications and cancer(15), Hemoglobinopathies and Related Disorders(13), CRISPR and Genetic Engineering(11), Chromosomal and Genetic Variations(10), Genomics and Chromatin Dynamics(9)

Publications50 total

Leveraging protein language models to identify complex trait associations with previously inaccessible classes of functional rare variants
Cell Genomics·2025Open Access
ERV-9 LTR Retrotransposon Modulates Globin Gene Switching
Blood·2018
Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness
UKnowledge (University of Kentucky)·2017Open Access
Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness
Haematologica·2017· 17 citedOpen Access
Hypermethylated LTR retrotransposon exhibits enhancer activity
Epigenetics·2017· 19 citedOpen Access
Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function
Nucleic Acids Research·2017· 44 citedOpen Access
UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
PLoS Genetics·2015· 179 citedOpen Access
Non-Coding RNAs Transcribed from ERV-9 LTR Retrotransposons Regulate Erythropoiesis
Blood·2014· 1 cited
In Human Beta-Globin Gene Locus, ERV-9 LTR Retrotransposon Interacts with and Activates Beta- but Not Gamma-Globin Gene
Blood·2014· 5 cited
NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene
PLoS ONE·2012· 43 citedOpen Access
Long-range function of an intergenic retrotransposon
Proceedings of the National Academy of Sciences·2010· 76 citedOpen Access
A facilitated tracking and transcription mechanism of long-range enhancer function
Nucleic Acids Research·2007· 85 citedOpen Access
Long-range function of the ERV-9 LTR in transcriptional regulation of the globin genes
Blood Cells Molecules and Diseases·2006
A Facilitated Tracking and Transcription Mechanism of the HS2 Enhancer in the β-Globin Locus Control Region.
Blood·2006
Gene amplification and associated loss of 5′ regulatory sequences of CoAA in human cancers
Oncogene·2006· 40 citedOpen Access
The Long Terminal Repeat (LTR) of ERV-9 Human Endogenous Retrovirus Binds to NF-Y in the Assembly of an Active LTR Enhancer Complex NF-Y/MZF1/GATA-2
Journal of Biological Chemistry·2005· 53 citedOpen Access
The HS2 Enhancer of the β-globin Locus Control Region Initiates Synthesis of Non-coding, Polyadenylated RNAs Independent of a cis-linked Globin Promoter
Journal of Molecular Biology·2005· 50 cited
HS2 Enhancer Function Is Blocked by a Transcriptional Terminator Inserted between the Enhancer and the Promoter
Journal of Biological Chemistry·2004· 79 citedOpen Access
The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans
Proceedings of the National Academy of Sciences·2004· 56 citedOpen Access
Dynamic retrotransposition of ERV-9 LTR and L1 in the β-globin gene locus during primate evolution
Molecular Phylogenetics and Evolution·2003· 5 cited
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Frequent Co-authors

Wenhu Pi(19), Jianhua Ling(11), Xingguo Zhu(10), Bernard G. Forget(6), Tianxiang Hu(5), Irving M. London(4), Pudur Jagadeeswaran(4), Yongchao Wang(4), James Bonner(3), P A Biro(3), Jon K. deRiel(3), Min Wu(3), Xiuping Yu(3), Chikh Bengra(3), F. Kutlar(3), Barry Whitney(3), Jeong-Hyeon Choi(3), Forget Bg(3), Weissman Sm(3), William B. Solomon(2)