Hugh A. Pearson

University of Leeds — United Kingdom

Neuroscience · Life Sciences

28h-index2.8kcitations57works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(32), Alzheimer's disease research and treatments(24), Ion channel regulation and function(24), Mitochondrial Function and Pathology(8), Nicotinic Acetylcholine Receptors Study(7)

Publications57 total

Molecular Properties of Lysine Dendrimers and their Interactions with Aβ-Peptides and Neuronal Cells
Current Medicinal Chemistry·2012· 60 cited
Peroxynitrite Mediates Disruption of Ca <sup>2+</sup> Homeostasis by Carbon Monoxide <i>via</i> Ca <sup>2+</sup> ATPase Degradation
Antioxidants and Redox Signaling·2012· 16 cited
Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells
Brain Research·2012· 9 cited
Carbon monoxide protects against oxidant‐induced apoptosis <i>via</i> inhibition of K <sub>v</sub> 2.1
The FASEB Journal·2011· 87 citedOpen Access
Gap junction-mediated spontaneous Ca2+ waves in differentiated cholinergic SN56 cells
Biochemical and Biophysical Research Communications·2010· 6 cited
α‐Synuclein modulation of Ca<sup>2+</sup>signaling in human neuroblastoma (SH‐SY5Y) cells
Journal of Neurochemistry·2009· 105 citedOpen Access
Hypoxia and Neurodegeneration
Annals of the New York Academy of Sciences·2009· 172 cited
Robotic multiwell planar patch-clamp for native and primary mammalian cells
Nature Protocols·2009· 107 citedOpen Access
Modulation of ‘A’-type K+ current by rodent and human forms of amyloid β protein
Neuroreport·2008· 20 cited
Differential involvement of TNFα in hypoxic suppression of astrocyte glutamate transporters
Glia·2008· 42 cited
Hypoxia suppresses astrocyte glutamate transport independently of amyloid formation
Biochemical and Biophysical Research Communications·2007· 29 cited
Hypoxia and Alzheimer’s disease
Essays in Biochemistry·2007· 84 cited
Calcium channel subtypes – another layer of complexity to an already intricate story
The Journal of Physiology·2006Open Access
Physiological roles for amyloid β peptides
The Journal of Physiology·2006· 278 citedOpen Access
Hypoxic Regulation of Ca2+ Signalling in Astrocytes and Endothelial Cells
Advances in experimental medicine and biology·2006· 1 cited
Chronic hypoxia inhibits Na+/Ca2+ exchanger expression in cortical astrocytes
Neuroreport·2006· 9 cited
Hypoxic Regulation of Ca <sup>2+</sup> Signalling in Astrocytes and Endothelial Cells
Novartis Foundation symposium·2006· 6 cited
Amyloid β peptide as a physiological modulator of neuronal ‘A’-type K+ current
Neurobiology of Aging·2005· 97 cited
A central role for ROS in the functional remodelling of L-type Ca <sup>2+</sup> channels by hypoxia
Philosophical Transactions of the Royal Society B Biological Sciences·2005· 21 citedOpen Access
Hypoxia stimulates Ca2+ release from intracellular stores in astrocytes via cyclic ADP ribose-mediated activation of ryanodine receptors
Cell Calcium·2005· 43 cited
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Frequent Co-authors

Chris Peers(30), John P. Boyle(20), Ian F. Smith(11), Leigh D. Plant(8), Annette Dolphin(8), Mark Dallas(7), Martin Ramsden(5), Z. Henderson(5), Roderick H. Scott(5), Jason L. Scragg(4), Nishani T. Hettiarachchi(4), Peter F. T. Vaughan(4), Hannah E. Boycott(3), Carol J. Milligan(3), Karen E. Porter(3), D. Wray(3), Nicola J. Webster(3), Paul J. Kemp(3), Kathy Sutton(3), Marva I. Sweeney(3)