Ching-Shih Chen

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index6.7kcitations93works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(21), Histone Deacetylase Inhibitors Research(20), Protein Kinase Regulation and GTPase Signaling(12), Protein Degradation and Inhibitors(11), Inflammatory mediators and NSAID effects(9)

Publications93 total

Retraction: Antitumor Effects of a Novel Phenylbutyrate-based Histone Deacetylase Inhibitor, (<i>S</i>)-HDAC-42, in Prostate Cancer
Clinical Cancer Research·2019
Editor's Note: From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors
Cancer Research·2019· 2 cited
Retraction: Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells
Carcinogenesis·2019· 1 citedOpen Access
Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway
Oncogene·2018· 53 cited
Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42
2017· 3 citedOpen Access
Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis
BMC Cancer·2017· 46 citedOpen Access
Pharmacological strategies to target oncogenic KRAS signaling in pancreatic cancer
Pharmacological Research·2017· 15 cited
Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer
Small GTPases·2016· 14 citedOpen Access
Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42
Neoplasia·2016· 17 citedOpen Access
Non‐immunosuppressive <scp>FTY720</scp>‐derivative <scp>OSU‐2S</scp> mediates reactive oxygen species‐mediated cytotoxicity in canine B‐cell lymphoma
Veterinary and Comparative Oncology·2016· 7 citedOpen Access
Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer
Carcinogenesis·2016· 24 citedOpen Access
Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function
Oncotarget·2016· 48 citedOpen Access
Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability
Oncotarget·2015· 32 citedOpen Access
Small Molecule T315 Promotes Casitas B-Lineage Lymphoma–Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation
American Journal of Respiratory and Critical Care Medicine·2015· 22 cited
Trastuzumab resistance induces EMT to transform HER2+ PTEN− to a triple negative breast cancer that requires unique treatment options
Scientific Reports·2015· 61 citedOpen Access
Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer
Oncotarget·2015· 48 citedOpen Access
Cellular prostatic acid phosphatase (cPAcP) serves as a useful biomarker of histone deacetylase (HDAC) inhibitors in prostate cancer cell growth suppression
Cell & Bioscience·2015· 10 citedOpen Access
Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer
Scientific Reports·2015· 102 citedOpen Access
Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6–Abundant Breast Cancer Cells by Regulating γ-Secretase–Mediated Notch1 Activation in Caveolae
Neoplasia·2015· 43 citedOpen Access
ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo
Experimental Hematology·2015· 22 citedOpen Access
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Frequent Co-authors

Samuel K. Kulp(16), Da-Sheng Wang(8), Ping‐Hui Tseng(8), Chang‐Shi Chen(8), Amy J. Johnson(7), John C. Byrd(7), Chung-Wai Shiau(6), Ho-Pi Lin(6), Chih-Cheng Yang(6), Ya-Ting Yang(5), Ao‐Lin Hsu(5), Rosa Lapalombella(5), Dasheng Wang(5), Natarajan Muthusamy(4), Jui-Wen Huang(4), Kuen‐Feng Chen(4), Yu-Chieh Wang(4), Meihua Yang(4), Po-Hsien Huang(4), Leslie A. Andritsos(4)