JoAnne Stubbe

Harvard University — United States

Chemistry · Physical Sciences

71h-index16.9kcitations284works0.02yr avg
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Research Topics

Metal-Catalyzed Oxygenation Mechanisms(157), Metal complexes synthesis and properties(79), Metalloenzymes and iron-sulfur proteins(40), CO2 Reduction Techniques and Catalysts(38), Photosynthetic Processes and Mechanisms(34)

Publications284 total

Mono-fluorotryptophans as probes of proton-coupled electron transfer in biology
Journal of Inorganic Biochemistry·2025Open Access
Decision letter: Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade
2022Open Access
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
Annual Review of Biochemistry·2020· 211 citedOpen Access
The road less traveled: For love of detection, discovery, and all things radical in nature
C&EN Global Enterprise·2020
Mapping allosteric transitions of an enzyme with SAXS, cryo-EM and crystallography
Acta Crystallographica Section A Foundations and Advances·2019Open Access
Convergent allostery in ribonucleotide reductase
Nature Communications·2019· 36 citedOpen Access
Convergent Allostery in Ribonucleotide Reductase
2018· 2 citedOpen Access
Catalysis by protein enzymes: Transcription of discussion
2018
A novel form of allosteric regulation in <i>Bacillus subtilis</i> ribonucleotide reductase revealed by SAXS and cryo-electron microscopy
Acta Crystallographica Section A Foundations and Advances·2018Open Access
BIOLOGICAL CATALYSIS: UNDERSTANDING RATE ACCELERATIONS IN ENZYMATIC REACTIONS
2018
Basis of dATP inhibition of RNRs
Journal of Biological Chemistry·2018· 6 citedOpen Access
An endogenous dAMP ligand in
DSpace@MIT (Massachusetts Institute of Technology)·2018Open Access
Author response: 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound
2018· 1 citedOpen Access
The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements
Journal of Biological Chemistry·2017· 26 citedOpen Access
Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer
Journal of Biological Chemistry·2017· 35 citedOpen Access
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator
Journal of Biological Chemistry·2016· 93 citedOpen Access
A &gt;200 meV Uphill Thermodynamic Landscape for Radical Transport in <i>Escherichia coli</i> Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes
Journal of the American Chemical Society·2016· 29 citedOpen Access
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: <i>E. coli</i> Ribonucleotide Reductase As an Example
Journal of the American Chemical Society·2016· 50 citedOpen Access
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes:
DSpace@MIT (Massachusetts Institute of Technology)·2016Open Access
Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase
Biochemistry·2016· 16 citedOpen Access
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Frequent Co-authors

Anthony J. Sinskey(8), Daniel G. Nocera(6), John W. Kozarich(4), J. Martin Bollinger(4), Jiamin Tian(4), Gregory M. York(4), Steven Y. Reece(3), Catherine L. Drennan(3), Joseph A. Cotruvo(3), Marina Bennati(3), Natarajan Ravi(3), Mohammad R. Seyedsayamdost(3), Cyril S. Yee(2), Jingyang Chen(2), Stuart Licht(2), Gary J. Gerfen(2), Ellen C. Minnihan(2), Dana E. Vanderwall(2), Boi Hanh Huynh(2), Dale E. Edmondson(2)