S Neben

Regulus Therapeutics (United States) — United States

Medicine · Health Sciences

26h-index2.5kcitations53works0.02yr avg

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Hematopoietic Stem Cell Transplantation(12), Immune Cell Function and Interaction(12), Hepatitis C virus research(10), T-cell and B-cell Immunology(8), Cancer Cells and Metastasis(8)

Publications53 total

Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth

127 cited

Nature Cell Biology·2022· 127 citedOpen Access

RGLS4326 Increases Urinary PC1 and PC2 Levels in Individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

4 cited

Journal of the American Society of Nephrology·2021· 4 cited

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease

185 cited

Nature Communications·2019· 185 citedOpen Access

Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site

15 cited

PLoS Pathogens·2019· 15 citedOpen Access

Impact of a Patient-Derived Hepatitis C Viral RNA Genome with a Mutated MicroRNA Binding Site

2018Open Access

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti‐MicroRNA‐122, RG‐101

52 cited

Hepatology·2017· 52 citedOpen Access

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

260 cited

The Lancet·2017· 260 cited

Sequence Analysis for Resistance Monitoring following a Single Dose of RG-101, an Anti-MIR Targeting Microrna-122, in Chronic Hepatitis C Patients

Journal of Hepatology·2016

A Single Dose of Anti-MIR122 Oligonucleotide RG-101 Results in a less Activated Phenotype of NK Cells in Patients with Chronic Hepatitis C

Journal of Hepatology·2016

RG-101 Demonstrates Favorable in Vitro Antiviral Activity and Cross Resistance Profile to Support Clinical Combination Studies in HCV Patients

Journal of Hepatology·2016

T Cell Functionality in Chronic Hepatitis C Patients Treated With the Anti-miR-122 RG-101

Hepatology·2016

LO7 : A single subcutaneous dose of 2mg/kg or 4mg/kg of RG-101, a GalNAc-conjugated oligonucleotide with antagonist activity against MIR-122, results in significant viral load reductions in chronic hepatitis C patients

10 cited

Journal of Hepatology·2015· 10 cited

P0907 : Pharmacokinetics, pharmacodynamics, and toxicity profile of RG-101, a novel GalNAc-conjugated hepatocyte-targetng inhibitor of microrna-122, in rodents and cynomolgus monkeys

3 cited

Journal of Hepatology·2015· 3 cited

P0904 : RG-101, A novel GalNAc-conjugated inhibitor of microrna-122, demonstrates significant viral load reduction and reduces liver steatosis in human hepatocyte chimeric mice infected with genotype 1A or hard-to-treat genotype 3A Hepatitis C Virus (HCV)

2 cited

Journal of Hepatology·2015· 2 cited

P1352 : Pharmacokinetics and pharmacology of RG-101, a novel GalNAc-conjugated oligonucleotide targeting microrna-122, in healthy volunteers

Journal of Hepatology·2015

A8.9 Neutralisation of miR-155 ameliorates collagen-induced arthritis

3 cited

Annals of the Rheumatic Diseases·2015· 3 cited

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

50 cited

Protein Engineering Design and Selection·2012· 50 citedOpen Access

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

102 cited

Proceedings of the National Academy of Sciences·2011· 102 citedOpen Access

Keratinocyte growth factor and the transcription factors C/EBPα, C/EBPδ, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells

1 cited

Journal of Clinical Investigation·2003· 1 citedOpen Access

Keratinocyte growth factor and the transcription factors C/EBPα, C/EBPδ, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells

70 cited

Journal of Clinical Investigation·2003· 70 citedOpen Access

page 1 of 3Next →

Frequent Co-authors

Xuguang Tai(6), Yumi Yashiro(6), Kazuhito Toyo‐oka(6), F. Stelma(5), Sophie B. Willemse(5), Marc van der Valk(5), Paul Grint(5), Neil W. Gibson(5), Peter Mauch(5), Ryo Abe(5), Michiko Kobayashi(5), Meike H. van der Ree(4), Neeltje A. Kootstra(4), Debra D. Donaldson(4), Katherine J. Turner(4), Adam Pavlı́c̀ek(3), Colin A. Sieff(3), James L.M. Ferrara(3), H Fujiwara(3), Fumiya Hirayama(3)