Shinji Hirotsune

Osaka City University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index6.8kcitations93works16.02yr avg
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Research Topics

Microtubule and mitosis dynamics(41), Cellular transport and secretion(14), Neuroscience and Neuropharmacology Research(10), Neurogenesis and neuroplasticity mechanisms(10), RNA Research and Splicing(8)

Publications86 total

Data from Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression
2023Open Access
Data from Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression
2023Open Access
Lis1 mutation prevents basal radial glia-like cell production in the mouse
Human Molecular Genetics·2021· 8 cited
Lis1 mutation prevents basal radial glia-like cell production in the mouse
2020Open Access
PB-09Alpha-synuclein Binds Unconventional Microtubules That Have a Unique Function
Microscopy·2017
Developmental Downregulation of LIS1 Expression Limits Axonal Extension and Allows Axon Pruning
2017· 1 citedOpen Access
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics
Scientific Reports·2017· 37 citedOpen Access
Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning
Biology Open·2017· 5 citedOpen Access
Developmental Alcohol Exposure Impairs Activity-Dependent<i>S-</i>Nitrosylation of NDEL1 for Neuronal Maturation
Cerebral Cortex·2016· 9 citedOpen Access
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway
The Journal of Cell Biology·2016· 73 citedOpen Access
Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules
Microscopy·2015· 3 cited
DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation
Journal of Neuroscience·2015· 23 citedOpen Access
Arl3 and LC8 regulate dissociation of dynactin from dynein
Nature Communications·2014· 16 citedOpen Access
1P192 微小管結合タンパク質シヌクレインは細胞質ダイニンを細胞辺縁部に運ぶ機能を持つ輸送性微小管の形成に必須である(12. 細胞生物的課題,ポスター,第52回日本生物物理学会年会(2014年度))
生物物理·2014
1P192 Synucleins are essential for the creation of transportable microtubules, which is required for anterograde transport of cytoplasmic dynein(12. Cell biology,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))
Seibutsu Butsuri·2014Open Access
The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex
Neuron·2013· 75 citedOpen Access
Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement
Nature Communications·2013· 28 citedOpen Access
Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans
eLife·2013· 126 citedOpen Access
Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly
Scientific Reports·2013· 20 citedOpen Access
Author response: Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans
2013· 2 citedOpen Access
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Frequent Co-authors

Anthony Wynshaw‐Boris(33), Masami Yamada(11), Kazuhito Toyo‐oka(9), Daisuke Mori(9), Shiori Toba(8), Atsushi Yoshiki(7), Masami Muramatsu(7), Yong Ha Youn(5), Tiziano Pramparo(5), Yoshihisa Yano(5), Yoko Y. Toyoshima(5), Michael J. Gambello(4), David H. Ledbetter(4), Shinji Sasaki(4), Kanako Kumamoto(4), Makoto Sato(4), Richard Paylor(3), Amy Chen(3), Noriyuki Yoshida(3), Yuko Yoshida(3)