George L. Spitalny

Medicine · Health Sciences

27h-index3.3kcitations60works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(15), Immune Cell Function and Interaction(12), Malaria Research and Control(9), T-cell and B-cell Immunology(7), Chronic Lymphocytic Leukemia Research(6)

Publications60 total

Targeted Delivery of Anti-Hepatitis B Antisense Oligonucleotides
2017· 1 cited
Alleviation of a lysosomal disease by a modified bacterial toxin
Molecular Genetics and Metabolism·2017
Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases
PLoS ONE·2016· 11 citedOpen Access
CO26. Results of a phase 1/2 study for KW-0761, a monoclonal antibody directed against CC chemokine receptor type 4 (CCR4), in CTCL patients
Melanoma Research·2011· 8 cited
Results of a Phase 1/2 Study for KW-0761, a Monoclonal Antibody Directed Against CC Chemokine Receptor Type 4 (CCR4), In CTCL Patients
Blood·2010· 27 cited
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma
Journal of Allergy and Clinical Immunology·2010· 276 cited
MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
Journal of Allergy and Clinical Immunology·2010· 567 cited
Monoclonal antibody therapy directed against interleukin-5 receptor α: MEDI-563
Progress in respiratory research/Progress in research in emphysema and chronic bronchitis/Progress in respiration research·2010· 1 cited
MEDI-563, a Humanized Anti-IL-5Ra Antibody with Enhanced Effector Function, Induces Reversible Blood Eosinopenia in Mild Asthmatics
Journal of Allergy and Clinical Immunology·2008· 10 cited
A DeImmunized chimeric anti-C3b/iC3b monoclonal antibody enhances rituximab-mediated killing in NHL and CLL cells via complement activation
Cancer Immunology Immunotherapy·2005· 20 citedOpen Access
Heteropolymers: a novel technology against blood-borne infections.
PubMed·2005· 12 cited
A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1)
Clinical & Experimental Immunology·2005· 30 citedOpen Access
A High-Affinity Monoclonal Antibody to Anthrax Protective Antigen Passively Protects Rabbits before and after Aerosolized <i>Bacillus anthracis</i> Spore Challenge
Infection and Immunity·2005· 123 citedOpen Access
Treatment with an Anti-C3b/iC3b Monoclonal Antibody as an Adjuvant to Rituximab Enhances the Killing of Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia Cells.
Blood·2004· 1 cited
An anti-C3b/iC3b monoclonal antibody (Mab) as an adjuvant to rituximab killing of non-Hodgkin's lymphoma (NHL) and chronical lymphocytic leukemia (CLL) cells
Journal of Clinical Oncology·2004
An anti-C3b/iC3b monoclonal antibody (Mab) as an adjuvant to rituximab killing of non-Hodgkin's lymphoma (NHL) and chronical lymphocytic leukemia (CLL) cells
Journal of Clinical Oncology·2004
Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages
Infection and Immunity·2004· 62 citedOpen Access
CD5-mediated specific delivery of DNA to T lymphocytes: compartmentalization augmented by adenovirus
Journal of Immunological Methods·1995· 23 citedOpen Access
Acyclovir–Glycoprotein conjugates are potent inhibitors of hepatitis B virus replication
Drug Delivery·1995· 1 cited
Targeted Delivery of DNA Using YEE(GalNAcAH)3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor
Bioconjugate Chemistry·1994· 94 cited
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Frequent Co-authors

Edward A. Havell(7), Peter A. Kiener(5), Nehal Mohamed(5), Leslie S. Casey(4), June Rae Merwin(4), Henry C. Chiou(4), Ruth S. Nussenzweig(4), R J North(4), Néstor A. Molfino(3), Anthony J. Coyle(3), Robert S. Greenfield(3), Mark A. Findeis(3), James R. Fahey(3), Roland Kolbeck(2), Masamichi Koike(2), Jennifer L. Reed(2), Jonas S. Erjefält(2), Alison A. Humbles(2), David Gossage(2), William W. Busse(2)