Andrew Siwkowski

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.7kcitations29works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(14), RNA Interference and Gene Delivery(12), Advanced biosensing and bioanalysis techniques(11), RNA and protein synthesis mechanisms(11), CRISPR and Genetic Engineering(3)

Publications29 total

Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides
Journal of Medicinal Chemistry·2010· 36 cited
An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA
Journal of the American Chemical Society·2010· 85 cited
Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue
Journal of Medicinal Chemistry·2010· 35 citedOpen Access
Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(<i>N</i>-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-<i>O</i>,4′-<i>C</i>-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models
Journal of Medicinal Chemistry·2010· 72 cited
Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN
Biochemical Pharmacology·2009· 82 cited
Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
Journal of Medicinal Chemistry·2008· 263 citedOpen Access
Optimization of Second-Generation Antisense Drugs: Going Beyond Generation 2.0
2007· 3 cited
Pharmacokinetic/Pharmacodynamic Properties ofPhosphorothioate 2'-O-(2-Methoxyethyl)-ModifiedAntisense Oligonucleotides in Animals and Man
2007· 7 cited
Optimization of Second-Generation Antisense Drugs
2007· 2 cited
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
Nucleic Acids Research·2006· 450 citedOpen Access
Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
Molecular Pharmacology·2006· 89 cited
Evaluation of Basic Amphipathic Peptides for Cellular Delivery of Antisense Peptide Nucleic Acids
Journal of Medicinal Chemistry·2006· 24 cited
Structure−Activity Relationship Study on a Simple Cationic Peptide Motif for Cellular Delivery of Antisense Peptide Nucleic Acid
Journal of Medicinal Chemistry·2005· 38 cited
Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression
Molecular Pharmacology·2004· 11 cited
Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing
Nucleic Acids Research·2004· 50 citedOpen Access
Design, Targeting, and Initial Screening of sTRSV- Derived Hairpin Ribozymes for Optimum Helix 1 Length and Catalytic Efficiency In Vitro
Humana Press eBooks·2004· 2 cited
Design of the Hairpin Ribozyme for Targeting Specific RNA Sequences
Humana Press eBooks·2003· 6 cited
Determination of Catalytic Parameters for Hairpin Ribozymes
Humana Press eBooks·2003· 11 cited
Mutagenesis and Modeling of the Hairpin Ribozyme Family
Humana Press eBooks·2003· 5 cited
T7 Transcript Length Determination Using Enzymatic RNA Sequencing
Humana Press eBooks·2003· 1 cited
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Frequent Co-authors

Arnold Hampel(10), Eric E. Swayze(9), Brett P. Monia(8), Edward V. Wancewicz(6), Michael T. Migawa(4), Punit P. Seth(4), Charles Allerson(4), Thazha P. Prakash(4), Hans Gaus(4), Mary Beth DeYoung(4), Guillermo Vasquez(3), Donna Witchell(3), Brenda F. Baker(3), Walt F. Lima(3), Andrés Berdeja(3), Richard S. Geary(3), Richard Shippy(3), Klaus Albertshofer(3), Garth A. Kinberger(3), Muthiah Manoharan(3)