José A. Łópez de Castro

Centro de Biología Molecular Severo Ochoa — Spain

Immunology and Microbiology · Life Sciences

43h-index5.1kcitations156works0.02yr avg
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Research Topics

T-cell and B-cell Immunology(95), Immunotherapy and Immune Responses(47), Immune Cell Function and Interaction(41), Monoclonal and Polyclonal Antibodies Research(39), Spondyloarthritis Studies and Treatments(38)

Publications156 total

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology·2022· 7 citedOpen Access
Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome: Implications for HLA-B*27-Negative Ankylosing Spondylitis
Molecular & Cellular Proteomics·2019· 10 citedOpen Access
Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome*[S]
Molecular & Cellular Proteomics·2019· 33 citedOpen Access
Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease
Human Immunology·2018· 66 cited
How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
Frontiers in Immunology·2018· 169 citedOpen Access
Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Molecular & Cellular Proteomics·2018· 26 citedOpen Access
Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome
Molecular & Cellular Proteomics·2018· 26 citedOpen Access
The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing
Journal of Biological Chemistry·2017· 66 citedOpen Access
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome
Journal of Autoimmunity·2017· 61 cited
Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view
Molecular Immunology·2016· 102 cited
Functional Interaction of the Ankylosing Spondylitis–Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA–B*27 Peptidome in Human Cells
Arthritis & Rheumatology·2016· 50 cited
The Peptidome of Behçet's Disease–Associated HLA–B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1
Arthritis & Rheumatology·2015· 67 cited
Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen*
Molecular & Cellular Proteomics·2015· 66 citedOpen Access
Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA–B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues
Arthritis & Rheumatology·2014· 41 citedOpen Access
Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
Molecular & Cellular Proteomics·2014· 39 citedOpen Access
Combined Effects of Ankylosing Spondylitis-associated ERAP1 Polymorphisms Outside the Catalytic and Peptide-binding Sites on the Processing of Natural HLA-B27 Ligands
Journal of Biological Chemistry·2013· 49 citedOpen Access
The pathogenesis of ankylosing spondylitis: HLA-B27 and beyond
Molecular Immunology·2013
ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases
Molecular Immunology·2013· 86 cited
Novel HLA-B27-restricted Epitopes from Chlamydia trachomatis Generated upon Endogenous Processing of Bacterial Proteins Suggest a Role of Molecular Mimicry in Reactive Arthritis
Journal of Biological Chemistry·2013· 41 citedOpen Access
ERAP1 in ankylosing spondylitis
Current Opinion in Rheumatology·2013· 19 cited
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Frequent Co-authors

Jack L. Strominger(7), Adrian Martín‐Esteban(7), Anabel Marina(6), Jesús Vázquez(6), Carlos Alvarez‐Navarro(6), Eilon Barnea(6), Arie Admon(6), Alberto Paradela(5), Manuel Ramos(5), Pablo Guasp(5), Alejandro Sanz‐Bravo(5), Rafael Bragado(5), Susana Rojo‐Alba(5), Harry T. Orr(4), Didier Rognan(4), Begoña Galocha(4), Miguel A. Vega(4), Pedro Aparício(4), Iñaki Álvarez(3), Miguel Marcilla(3)