Kazuko Fujisawa

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index3.4kcitations23works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(11), Microtubule and mitosis dynamics(4), Cellular transport and secretion(3), Axon Guidance and Neuronal Signaling(3), Neuroscience and Neuropharmacology Research(2)

Publications23 total

Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy
Neurobiology of Disease·2024Open Access
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease
Nature Communications·2023· 45 citedOpen Access
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Molecular Neurodegeneration·2021· 26 citedOpen Access
The Slit Receptor EVA-1 Coactivates a SAX-3/Robo–Mediated Guidance Signal in <i>C. elegans</i>
Science·2007· 64 cited
C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor
Neuron·2001· 237 citedOpen Access
Cupidin, an Isoform of Homer/Vesl, Interacts with the Actin Cytoskeleton and Activated Rho Family Small GTPases and Is Expressed in Developing Mouse Cerebellar Granule Cells
Journal of Neuroscience·1999· 102 citedOpen Access
Citron, a Rho-Target, Interacts with PSD-95/SAP-90 at Glutamatergic Synapses in the Thalamus
Journal of Neuroscience·1999· 97 citedOpen Access
Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules
Journal of Biological Chemistry·1998· 119 citedOpen Access
Role of citron kinase as a target of the small GTPase Rho in cytokinesis
Nature·1998· 393 cited
Citron, a Rho-target, interacts with PSD-95 at glutamatergic synapses in the thalamus
Neuroscience Research·1998
Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets
Biochemical Journal·1997· 35 citedOpen Access
p160<sup>ROCK</sup>, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions
FEBS Letters·1997· 510 citedOpen Access
p160ROCK, a Rho-associated coiled-coil forming protein kinase, induces focal adhesions downstream of Rho
The Japanese Journal of Pharmacology·1997Open Access
Identification of the Rho-binding Domain of p160 , a Rho-associated Coiled-coil Containing Protein Kinase
Journal of Biological Chemistry·1996· 140 citedOpen Access
ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice
FEBS Letters·1996· 796 citedOpen Access
Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain
Journal of Biological Chemistry·1996· 373 citedOpen Access
Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho
Science·1996· 389 cited
Identification of a putative Rho target molecule as a serine/threonine kinase, p160ROCK
The Japanese Journal of Pharmacology·1996Open Access
Lysophosphatidic acid‐induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts Possible involvement in <i>rho</i><i>p</i>21‐mediated signalling
FEBS Letters·1995· 22 citedOpen Access
ADP-ribosylation of the rho gene product: II, Inhibition of LPA-induced protein tyrosine phosphorylation and activation of MAP-kinase and PI3-kinase.
The Japanese Journal of Pharmacology·1994Open Access
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Frequent Co-authors

Shuh Narumiya(14), Toshimasa Ishizaki(11), Yuji Saito(9), Narito Morii(7), Naoki Watanabe(6), Pascal Madaule(6), Haruhiko Bito(5), Akiko Fujita(5), Midori Maekawa(4), Naokazu Kumagai(4), Shuh Narumiya(3), Go Watanabe(3), Tomoyuki Furuyashiki(3), Joseph G. Culotti(3), Minesh Kapadia(3), Suneil K. Kalia(3), Lorraine V. Kalia(3), Kazuwa Nakao(2), Mamoru Naito(2), Akira Kakizuka(2)