Christopher Bebbington

Curtin University — Australia

Immunology and Microbiology · Life Sciences

21h-index2.1kcitations47works0.02yr avg
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Research Topics

Mast cells and histamine(9), Eosinophilic Disorders and Syndromes(9), Monoclonal and Polyclonal Antibodies Research(8), Axon Guidance and Neuronal Signaling(8), Eosinophilic Esophagitis(8)

Publications47 total

Investor decision making within retirement savings schemes
Pacific-Basin Finance Journal·2023· 4 cited
Supplementary Methods, Tables 1 - 2, Figures 1 - 8 from Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
2023Open Access
Data from Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
2023Open Access
Supplementary Methods, Tables 1 - 2, Figures 1 - 8 from Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
2023Open Access
Data from Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
2023Open Access
Discovery, Function, and Therapeutic Targeting of Siglec-8
Cells·2020· 81 citedOpen Access
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation
Mucosal Immunology·2020· 73 citedOpen Access
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis
JCI Insight·2019· 103 citedOpen Access
Mo1163 – Eg and Eoe Patient Biopsies Have High Numbers of Activated Eosinophils and Mast Cells that are Inhibited by Ak002
Gastroenterology·2019
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
International Archives of Allergy and Immunology·2019· 104 citedOpen Access
Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies
Journal of Allergy and Clinical Immunology·2018· 58 citedOpen Access
AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis
Blood·2018· 4 cited
Novel Anti-Siglec-8 Antibody Reduces Eosinophil and Mast Cell Infiltration in a Mouse Model of Eosinophilic Gastroenteritis
The American Journal of Gastroenterology·2018
Siglec—8, a Novel Selective Target for Eosinophilic Gastrointestinal Diseases (EGIDs) Found on Eosinophils and Mast Cells in Human Tissue
The American Journal of Gastroenterology·2018
352 - AK002, a First-in-Class, Humanized, Non-Fucosylated IGG1 Siglec-8 Antibody, Selectively Depletes Blood and Tissue Eosinophils
Gastroenterology·2018· 1 cited
353 - Anti-Siglec-8 Antibody Reduces Eosinophil and Mast Cell Infiltration in a Mouse Model of Eosinophilic Gastritis: A Novel Therapeutic Approach for Eosinophilic Gastrointestinal Diseases
Gastroenterology·2018· 2 cited
A Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Phase 1 Study of AK002, a Novel Siglec-8 Selective Monoclonal Antibody, in Healthy Subjects
Journal of Allergy and Clinical Immunology·2018· 26 cited
Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Journal of Allergy and Clinical Immunology·2016· 100 cited
A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients
Blood·2015· 4 cited
Immunotherapeutic Targeting of EphA3
Blood·2014· 1 cited
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Frequent Co-authors

Geoffrey Yarranton(20), Nenad Tomas̆ević(18), Mark Baer(14), John Leung(13), Bradford A. Youngblood(11), Emily C. Brock(11), Varghese Palath(11), Martin Lackmann(10), Andrew M. Scott(9), Rustom Falahati(6), Alan F. List(5), J.C. Williams(5), Mary E. Vail(5), Carmel Murone(5), April Tan(5), Linda Hii(5), Peter W. Janes(5), Carmen Llerena(5), Slavisa Garic(5), Glenn A. Cartwright(5)