Daisuke Koyama

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index825citations24works0.02yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(7), Epigenetics and DNA Methylation(6), Multiple Myeloma Research and Treatments(4), Acute Lymphoblastic Leukemia research(4), Ubiquitin and proteasome pathways(4)

Publications24 total

Prediction of possible new drug binding site for ATP-sensitive potassium channel inhibition: bupropion’s modulation of hippocampal CA1 neuron excitability
Neuroreport·2025
Autophagic degradation of NOXA underlies stromal cell-mediated resistance to proteasome inhibitors in mantle cell lymphoma
Leukemia Research·2021· 3 cited
mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3- and Blimp-1-mediated BCL-2 upregulation
Haematologica·2021· 12 citedOpen Access
Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma
Journal of Clinical and Experimental Hematopathology·2021· 3 citedOpen Access
Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features
Frontiers in Oncology·2020· 16 citedOpen Access
AMP‐activated protein kinase activation primes cytoplasmic translocation and autophagic degradation of the BCR‐ABL protein in CML cells
Cancer Science·2020· 16 citedOpen Access
Bone marrow stromal cell-mediated degradation of CD20 leads to primary rituximab resistance in mantle cell lymphoma
Leukemia·2020· 3 cited
Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients
Internal Medicine·2020· 22 citedOpen Access
Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7
Leukemia·2019· 66 cited
Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor
Clinical Cancer Research·2018· 23 cited
Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide
Cancer Research·2018· 29 cited
Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells
International Journal of Hematology·2017
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma
Journal of Clinical Investigation·2015· 96 citedOpen Access
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma
Experimental Hematology·2015· 2 citedOpen Access
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates airway epithelial barrier integrity
Allergology International·2015· 52 citedOpen Access
Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation
Blood·2015· 53 citedOpen Access
Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma
Blood Cancer Journal·2013· 17 citedOpen Access
Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia
Leukemia·2013· 65 citedOpen Access
Impact of Macrophage Activation on Delayed Engraftment Following Allogeneic Hematopoietic Stem Cell Transplantation: Mac Ratio, a New Predictive Index
Blood·2013
The Novel Orally Active Proteasome Inhibitor K-7174 Exerts Anti-myeloma Activity in Vitro and in Vivo by Down-regulating the Expression of Class I Histone Deacetylases
Journal of Biological Chemistry·2013· 27 citedOpen Access
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Frequent Co-authors

Yusuke Furukawa(15), Jiro Kikuchi(14), Yoshiaki Kuroda(8), Taeko Wada(6), Tohru Izumi(5), Hiroshi Yasui(3), Naoki Osada(3), Yukiyasu Ozawa(3), Koichi Miyamura(3), Masafumi Ito(3), Yoshihiro Uto(2), Hideko Nagasawa(2), Hitoshi Hori(2), Peter O. Hofgaard(2), Bjarne Bogen(2), Nobuya Hiraoka(2), Tatsuo Ichinohe(2), Satoshi Nishiwaki(2), Emi Yokohata(2), Sonoko Kamoshita(2)