Willard Lew

University of Sydney — Australia

Medicine · Health Sciences

26h-index5.7kcitations56works2.52yr avg
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Research Topics

Influenza Virus Research Studies(17), Carbohydrate Chemistry and Synthesis(12), Chemical Synthesis and Analysis(11), Microtubule and mitosis dynamics(5), HIV/AIDS drug development and treatment(5)

Publications56 total

Rapid On-Demand Point-of-Care Monitoring of Clozapine and Its Metabolite Norclozapine Using Miniature Mass Spectrometry
Pharmaceuticals·2025· 1 citedOpen Access
Early Process Development of an LPAR1 Antagonist, GS-2278
Organic Process Research & Development·2024· 4 cited
Process Development and Scale-Up of a Protease Inhibitor for the Treatment of HIV Featuring the Preparation of a Neopentyl Grignard Reagent and Development of a One-Pot Curtius Reaction
Organic Process Research & Development·2022· 4 cited
In the pipeline Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer
2020
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Bioorganic & Medicinal Chemistry Letters·2017· 7 citedOpen Access
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Journal of Medicinal Chemistry·2017· 648 citedOpen Access
CCDC 1525480: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017· 1 citedOpen Access
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Nature·2016· 1.6k citedOpen Access
CCDC 1445315: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates
Open Forum Infectious Diseases·2015· 63 citedOpen Access
CCDC 929321: Experimental Crystal Structure Determination
The Cambridge Structural Database·2014Open Access
CCDC 929320: Experimental Crystal Structure Determination
The Cambridge Structural Database·2014Open Access
Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Journal of Medicinal Chemistry·2013· 36 cited
Discovery of the First <i>C</i>-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients
Journal of Medicinal Chemistry·2013· 125 cited
Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
Antimicrobial Agents and Chemotherapy·2012· 40 citedOpen Access
Neuraminidase Inhibitors as Anti‐Influenza Agents
Methods and principles in medicinal chemistry·2011· 1 cited
A Practical Synthesis of 1-N-SEM-Protected 3-Iodo-7-methyl-2-piperidin-3-ylindole
Synthesis·2009· 7 cited
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 41 citedOpen Access
Water-soluble prodrugs of an Aurora kinase inhibitor
Bioorganic & Medicinal Chemistry Letters·2009· 21 cited
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 31 citedOpen Access
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Frequent Co-authors

Dirk B. Mendel(16), Choung U. Kim(15), Paul A. Escarpe(13), Edward Doerffler(11), Michael O. Clarke(10), Adrian S. Ray(9), Lijun Zhang(9), Joy Y. Feng(9), S. Swaminathan(8), Matthew A. Williams(8), Sean Neville(7), Travis K. Warren(6), Richard L. Mackman(6), Veronica Soloveva(6), Robert G. Strickley(6), Queenie Wang(6), Kwon Soo Chun(6), Darius Babusis(6), Kirsten M. Stray(6), Ona Barauskas(6)