Thomas G. Burke

Yale University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index3.9kcitations91works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(41), Antibiotics Pharmacokinetics and Efficacy(14), Neutropenia and Cancer Infections(13), Protein Interaction Studies and Fluorescence Analysis(12), Lipid Membrane Structure and Behavior(11)

Publications90 total

Disinfection of Hospital Sink Drains Enriches Pseudomonadota and Efflux Pump-Mediated Antibiotic Resistance in Reestablished Biofilms
2025Open Access
SEM study of simulated clinical use for four nickel–titanium rotary endodontic files
Medical Devices & Sensors·2019· 2 citedOpen Access
AN SEM INVESTIGATION INTO THE EFFECTS OF CLINICAL USE ON HEAT-TREATED NICKEL-TITANIUM ROTARY ENDODONTIC FILES
OhioLink ETD Center (Ohio Library and Information Network)·2016Open Access
An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells
International Journal of Pharmaceutics·2008· 148 cited
Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice
Investigational New Drugs·2008· 7 cited
Camptothecins in Cancer Therapy
Humana Press eBooks·2005· 30 citedOpen Access
Recent Advances in Camptothecin Drug Design and Delivery Strategies
Humana Press eBooks·2005· 8 cited
The Novel Highly Lipophilic Topoisomerase I Inhibitor DB67 Is Effective in the Treatment of Liver Metastases of Murine CT-26 Colon Carcinoma
Neoplasia·2004· 19 citedOpen Access
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies
Bioorganic & Medicinal Chemistry·2004· 20 cited
Degradation of camptothecin-20(S)-glycinate ester prodrug under physiological conditions
Journal of Pharmaceutical and Biomedical Analysis·2004· 15 cited
Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection
Journal of Chromatography B·2003· 2 cited
Applications of fluorescence spectroscopy and dynamic light scattering in biotechnology of camptothecins: promising anticancer drugs
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE·2003· 1 cited
A Versatile Prodrug Approach for Liposomal Core-Loading of Water-Insoluble Camptothecin Anticancer Drugs
Journal of the American Chemical Society·2002· 44 cited
ChemInform Abstract: Synthesis and Evaluation of a Novel E‐Ring Modified α‐Hydroxy Keto Ether Analogue of Camptothecin.
ChemInform·2002
Camptothecins affinity to HSA and membranes determined by fluorescence anisotropy measurements
Optica Applicata·2002· 11 cited
Synthesis and evaluation of a novel E-ring modified α-hydroxy keto ether analogue of camptothecin
Bioorganic & Medicinal Chemistry·2002· 28 cited
The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity
Journal of Controlled Release·2001· 51 cited
Images in preventive medicine
American Journal of Preventive Medicine·2001
Diseases of Domestic Guinea Pigs, 2nd ed.
Journal of Zoo and Wildlife Medicine·2000· 7 cited
Campthotecin Design and Delivery Approaches for Elevating Anti‐Topoisomerase I Activities <i>in Vivo</i>
Annals of the New York Academy of Sciences·2000· 40 cited
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Frequent Co-authors

David Bom(6), Dennis P. Curran(6), Thomas R. Tritton(6), Zihou Mi(5), Stefan Kruszewski(4), Wu Du(4), Alok Singh(4), Jun Zhang(4), Stephen G. Zimmer(3), J. Thompson Strode(3), Yves Pommier(3), Henryk Malak(3), Waldemar Priebe(3), Alan S. Rudolph(3), Zihou Mi(2), Anna Shenderova(2), Glenda Kohlhagen(2), Ashok J. Chavan(2), Kimberly A. Fraley(2), Alex L. Bingcang(2)