Shigeru Sassa

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index10.4kcitations260works0.02yr avg
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Research Topics

Porphyrin Metabolism and Disorders(158), Heme Oxygenase-1 and Carbon Monoxide(149), Neonatal Health and Biochemistry(100), Folate and B Vitamins Research(45), Metabolism and Genetic Disorders(27)

Publications259 total

The Porphyrias
2018
Inhibition of the growth and differ( cells by an endotoxin-induced medi peritoneal macrophages (cell differentiation/growth inhibition/erythropoiesis/macrophage pl
2016
A Microassay for Uroporphyrinogen I Syl Enzyme Activities in Acute Intermittent P to the Study of the Genetics of this Diseas
2016
Delta-Aminolevulinate-Induced Host-Parasite Porphyric Disparity for Selective Photolysis of Transgenic Leishmania in the Phagolysosomes of Mononuclear Phagocytes: a Potential Novel Platform for Vaccine Delivery
Eukaryotic Cell·2012· 9 citedOpen Access
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway
FEBS Journal·2008· 18 citedOpen Access
Transgenic<i>Leishmania</i>Model for Delta-Aminolevulinate-Inducible Monospecific Uroporphyria: Cytolytic Phototoxicity Initiated by Singlet Oxygen-Mediated Inactivation of Proteins and Its Ablation by Endosomal Mobilization of Cytosolic Uroporphyrin
Eukaryotic Cell·2008· 20 citedOpen Access
Leishmania spp.: Delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway
Experimental Parasitology·2007· 26 citedOpen Access
Analyses of Heme-Regulated Genes during Erythoid Differentiation.
Blood·2007
Heme Oxygenase-1: A Fundamental Guardian Against Oxidative Tissue Injuries in Acute Inflammation
Mini-Reviews in Medicinal Chemistry·2007· 69 cited
Gene regulation by free heme
Folia Pharmacologica Japonica·2007· 3 citedOpen Access
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity
International Journal of Molecular Medicine·2006· 32 citedOpen Access
Modern diagnosis and management of the porphyrias
British Journal of Haematology·2006· 191 citedOpen Access
Defense Against Oxidative Tissue Injury: The Essential Role Played by Heme Oxygenase-1
Current Enzyme Inhibition·2006· 11 cited
Heme oxygenase‐1: a new drug target in oxidative tissue injuries in critically ill conditions
Drug Development Research·2006· 7 cited
Akagi R, Inoue R, Muranaka S et al.Dual gene defects involving δ-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient. Br J Haematol 132:237-243
2006· 4 cited
Biological Implications of Heme Metabolism
Journal of Clinical Biochemistry and Nutrition·2006· 51 citedOpen Access
δ-Aminolevulinate dehydratase (ALAD) porphyria: The first case in North America with two novel ALAD mutations
Molecular Genetics and Metabolism·2005· 49 cited
Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: Identification of novel heme-regulated genes
Biochemical and Biophysical Research Communications·2005· 12 cited
Dual gene defects involving <i>δ</i>‐aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient
British Journal of Haematology·2005· 28 citedOpen Access
Arg452 substitution of the erythroid‐specific 5‐aminolaevulinate synthase, a hot spot mutation in X‐linked sideroblastic anaemia, does not itself affect enzyme activity
European Journal Of Haematology·2005· 17 cited
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Frequent Co-authors

Attallah Kappas(21), S. Granick(8), J. Granick(4), R D Levere(4), Hiroko Shimizu(4), Toru Takahashi(3), Kaoru Morita(3), Kazumichi Furuyama(3), Norio Hayashi(3), Masayuki Yamamoto(3), Alvito P. Alvares(3), Karl E. Anderson(3), Hideaki Fujita(3), Reiko Akagi(3), Reiko Akagi(2), Richard A. Galbraith(2), Tsukasa Yoshinaga(2), Kinuko Mitani(2), Q W Xie(2), Hiromi Fujii(2)