Julian Leathart

Newcastle upon Tyne Hospital — United Kingdom

Medicine · Health Sciences

27h-index5.0kcitations54works0.02yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(14), Pharmacogenetics and Drug Metabolism(13), Drug Transport and Resistance Mechanisms(8), Alcohol Consumption and Health Effects(7), Diet, Metabolism, and Disease(7)

Publications54 total

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Nature Communications·2014· 603 citedOpen Access
Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease
Cell Cycle·2014· 69 citedOpen Access
Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
Journal of Hepatology·2014· 522 citedOpen Access
A Randomized Trial of Genotype-Guided Dosing of Warfarin
New England Journal of Medicine·2013· 802 citedOpen Access
1275 CARRIAGE OF PNPLA3 I148M IS ASSOCIATED WITH AN INCREASED RISK OF NON-ALCOHOLIC FATTY LIVER DIESEASE ASSOCIATED HEPATOCELLULAR CARCINOMA
Journal of Hepatology·2013· 7 cited
104 A CANDIDATE-GENE APPROACH TO VALIDATION OF GENETIC MODIFIER ASSOCIATIONS USING A LARGE COHORT WITH HISTOLOGICALLY CHARACTERISED NON-ALCOHOLIC FATTY LIVER DISEASE
Journal of Hepatology·2013· 11 citedOpen Access
VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children
Blood·2011· 107 citedOpen Access
Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon® probes
Clinica Chimica Acta·2011· 37 citedOpen Access
The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver
Journal of Hepatology·2011· 82 cited
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies
Journal of Hepatology·2011· 189 citedOpen Access
Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility
Pancreas·2011· 11 cited
BCMO1 deficiency induces nonalcoholic steatohepatitis independent of fatty acid oxidation and synthesis
Acta Biologica Cracoviensia. Series Zoologia·2011
Mitochondrial DNA does not contribute to the heritability of non-alcoholic fatty liver disease
Mitochondrion·2010· 4 cited
Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility
Toxicology Letters·2010
Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease
Gut·2010· 171 cited
The Kruppel-Like Factor 6 Genotype Is Associated With Fibrosis in Nonalcoholic Fatty Liver Disease
Gastroenterology·2008· 193 citedOpen Access
[22] THE KLF6 (IVS1-27G > A) POLYMORPHISM IS ASSOCIATED WITH NON-PROGRESSIVE NAFLD
Journal of Hepatology·2007
[704] MITOCHONDRIAL DNA HAPLOGROUPS ASSOCIATED WITH HISTOLOGICAL SEVERITY IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Journal of Hepatology·2007
The mitochondrial superoxide dismutase 2 (SOD2) targeting sequence polymorphism is associated with fibrotic NAFLD: Consistent evidence from case-control and intra-familial allelic association studies
2007· 6 cited
Genetic evidence that lipid trafficking plays a key role in fibrosis in non alcoholic fatty liver disease
2007
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Frequent Co-authors

Ann K. Daly(42), Christopher P. Day(15), Guruprasad P. Aithal(10), Alastair D. Burt(7), Helen L. Reeves(6), Quentin M. Anstee(6), Jeffrey R. Idle(6), Chris Day(6), Valério Nobili(4), Luca Valenti(4), C.P. Day(4), Graeme Alexander(3), Gillian Patman(3), Elaine Mutch(3), Faith M. Williams(3), Martin Armstrong(3), Ahmad Al‐Serri(3), Paola Dongiovanni(3), Anna Ludovica Fracanzani(3), Silvia Fargion(3)