Gopuraja Dharmalingam

Eli Lilly (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index5.1kcitations47works1.02yr avg
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Research Topics

Genomics and Chromatin Dynamics(9), CRISPR and Genetic Engineering(7), Telomeres, Telomerase, and Senescence(7), Cancer-related molecular mechanisms research(6), Single-cell and spatial transcriptomics(6)

Publications47 total

Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease
Neurobiology of Disease·2025· 1 citedOpen Access
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nature Cell Biology·2024· 1 citedOpen Access
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
Nature Cell Biology·2023· 48 citedOpen Access
Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease
Nature Communications·2023· 15 citedOpen Access
Galectin-3 activates microglia in arthritic pain: a process defective in Alzheimer’s disease mice
Figshare·2023Open Access
Estrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause
Nature Cardiovascular Research·2022· 22 citedOpen Access
Author response: Cohesin-dependence of neuronal gene expression relates to chromatin loop length
2022Open Access
Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
Nature Communications·2021· 44 citedOpen Access
Reliance of neuronal gene expression on cohesin scales with chromatin loop length
2021· 7 citedOpen Access
XPO7 is a tumor suppressor regulating p21<sup>CIP1</sup>-dependent senescence
Genes & Development·2021· 24 citedOpen Access
Partial rescue of neuronal genes deregulated in Cornelia de Lange Syndrome by cohesin
2020· 1 citedOpen Access
LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites
Mobile DNA·2020· 12 citedOpen Access
Metadata record for: STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse
Figshare·2020Open Access
Additional file 2 of LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites
Figshare·2020Open Access
Additional file 3 of LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites
Figshare·2020Open Access
STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse
Scientific Data·2019· 33 citedOpen Access
Cardiac glycosides are broad-spectrum senolytics
Nature Metabolism·2019· 337 citedOpen Access
Metadata record for: STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse
Figshare·2019Open Access
Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system
Nature Immunology·2019· 20 cited
Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation
PLoS Biology·2019· 10 citedOpen Access
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Frequent Co-authors

Matthias Merkenschlager(19), Amanda G. Fisher(14), Thomas Carroll(13), Jesús Gil(11), Thomas Carroll(7), Anthony G. Uren(7), Isabel Ferreirós-Vidal(7), Ziwei Liang(7), Athena Georgilis(6), Lars Zender(6), Yi-Fang Wang(6), Boris Lenhard(6), David Gómez-Cabrero(6), Sonia Tarazona(6), Ricardo N. Ramírez(6), Lauren Cooper(6), Ioannis Tsamardinos(6), A Mortazavi(6), Jesper Tegnér(6), Joanna Dawes(6)