Mario Lo Bello

University of Rome Tor Vergata — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index4.0kcitations77works0.02yr avg
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Research Topics

Glutathione Transferases and Polymorphisms(70), Genomics, phytochemicals, and oxidative stress(53), Pharmacogenetics and Drug Metabolism(15), Metal complexes synthesis and properties(7), Folate and B Vitamins Research(7)

Publications77 total

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
Proceedings of the National Academy of Sciences·2019· 95 citedOpen Access
Organometallic Glutathione <i>S</i>-Transferase Inhibitors
Organometallics·2017· 31 citedOpen Access
CCDC 1555830: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Nitric Oxide Interacting with Glutathione Transferases
Elsevier eBooks·2017
Contributors
Elsevier eBooks·2017
Glutathione transferase P1‐1 as an arsenic drug‐sequestering enzyme
Protein Science·2016· 24 citedOpen Access
Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function
Journal of Biological Chemistry·2016· 28 citedOpen Access
Glutathione transferases and neurodegenerative diseases
Neurochemistry International·2015· 121 cited
The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily
Journal of Biological Chemistry·2013· 34 citedOpen Access
Platinum- and Ruthenium-Based Anticancer Compounds, Inhibition of Glutathione Transferase P1-1
2013· 1 citedOpen Access
A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin
Journal of Inorganic Biochemistry·2012· 47 citedOpen Access
Glutathione S-transferase alpha 1 risk polymorphism and increased bilateral thalamus mean diffusivity in schizophrenia
Psychiatry Research Neuroimaging·2012· 13 cited
Identifying and Characterizing Binding Sites on the Irreversible Inhibition of Human Glutathione S‐Transferase P1‐1 by <i>S</i>‐Thiocarbamoylation
ChemBioChem·2012· 10 cited
Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance
Biochemical Journal·2011· 88 citedOpen Access
Cover Picture: Studies of Glutathione Transferase P1‐1 Bound to a Platinum(IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation (Chem. Eur. J. 28/2011)
Chemistry - A European Journal·2011
Studies of Glutathione Transferase P1‐1 Bound to a Platinum(IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation
Chemistry - A European Journal·2011· 76 citedOpen Access
Diuretic drug binding to human glutathione transferase P1‐1: potential role of Cys‐101 revealed in the double mutant C47S/Y108V
Journal of Molecular Recognition·2010· 15 citedOpen Access
Monomer−Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination
Biochemistry·2009· 106 citedOpen Access
Influence of the H‐site residue 108 on human glutathione transferase P1‐1 ligand binding: Structure‐thermodynamic relationships and thermal stability
Protein Science·2009· 20 citedOpen Access
Rational Design of an Organometallic Glutathione Transferase Inhibitor
Angewandte Chemie·2009· 21 cited
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Frequent Co-authors

Giorgio Federici(33), Giorgio Ricci(27), Michael W. Parker(25), Anna Maria Caccuri(21), Marzia Nuccetelli(12), Anna P. Mazzetti(12), Aaron J. Oakley(8), Lorenzo Stella(8), Giovanni Antonini(8), L.J. Parker(7), Anastasia De Luca(7), Jens Z. Pedersen(7), Paola Turella(7), Craig J. Morton(6), Paul J. Dyson(6), Maria Rita Nicotra(6), Philip G. Board(6), Andrea Battistoni(5), Jamie Rossjohn(5), Francesca De Maria(5)