Chuangxing Guo

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.6kcitations47works0.02yr avg
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Research Topics

Phytochemical Studies and Bioactivities(8), Signaling Pathways in Disease(7), Prostate Cancer Treatment and Research(6), Crystallization and Solubility Studies(5), Peptidase Inhibition and Analysis(5)

Publications47 total

A first-in-human phase 1 study of proxalutamide (GT0918), a dual MOA androgen receptor blocker in patients with advanced CRPC.
Journal of Clinical Oncology·2017
Abstract 614: Proxalutamide (GT0918), a potent androgen receptor pathway inhibitor
Cancer Research·2014· 15 cited
Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket
Bioorganic & Medicinal Chemistry Letters·2014· 49 citedOpen Access
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators
Bioorganic & Medicinal Chemistry Letters·2013· 46 citedOpen Access
Abstract 2460: Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer.
Cancer Research·2013· 1 cited
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction
Bioorganic & Medicinal Chemistry Letters·2012· 5 citedOpen Access
Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors
Journal of Medicinal Chemistry·2012· 59 citedOpen Access
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 24 citedOpen Access
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer
Bioorganic & Medicinal Chemistry Letters·2011· 12 citedOpen Access
ChemInform Abstract: An Efficient Synthesis of Highly Functionalized Chiral Lactams.
ChemInform·2011
Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists
Journal of Medicinal Chemistry·2011· 67 citedOpen Access
Systematic Structure Modifications of Imidazo[1,2-<i>a</i>]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)
Journal of Medicinal Chemistry·2011· 80 cited
An efficient synthesis of highly functionalized chiral lactams
Tetrahedron Letters·2011· 7 cited
A novel method to enable SNAr reaction of aminopyrrolopyrazoles
Tetrahedron Letters·2011· 6 cited
ChemInform Abstract: An Efficient Synthesis of Sulfamides.
ChemInform·2010
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
Proceedings of the National Academy of Sciences·2010· 318 citedOpen Access
An efficient synthesis of sulfamides
Tetrahedron Letters·2010· 15 cited
Structure-based design of novel human Pin1 inhibitors (II)
Bioorganic & Medicinal Chemistry Letters·2010· 86 cited
Abstract B169: Characterization of <i>in vitro</i> activity and predictive biomarkers of the novel p21-activated kinase 4 (PAK4) inhibitor, PF-3758309, in colorectal cancer cell lines
Molecular Cancer Therapeutics·2009
Abstract PR-2: Discovery of p21-activated kinase inhibitor PF-03758309
Molecular Cancer Therapeutics·2009· 2 cited
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Frequent Co-authors

Susan E. Kephart(14), P. L. Fuchs(13), Liming Dong(13), Thomas Lacour(9), Angelica Linton(8), Mason Pairish(8), Eric Block(8), Mohan Thiruvazhi(8), Brion W. Murray(7), Joseph Marakovits(7), Martha A. Ornelas(7), Eleanor Dagostino(6), Xinjun Hou(6), S.E. Greasley(6), Joseph Piraino(5), Eugenia Kraynov(5), Sudhakar Bhandaru(5), Paul Richardson(5), Chunhong He(5), Paul J. Toscano(5)