C. Richard Lyttle

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index6.4kcitations104works0.02yr avg
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Research Topics

Estrogen and related hormone effects(57), Reproductive System and Pregnancy(45), Endometriosis Research and Treatment(14), Effects and risks of endocrine disrupting chemicals(12), Coagulation, Bradykinin, Polyphosphates, and Angioedema(11)

Publications104 total

Keratinocyte cancer of the lower limb in the frail elderly – acceptable results for 96 lesions treated with a shortened radiotherapy protocol
International Journal of Radiology & Radiation Therapy·2024Open Access
Naloxone Prescriptions Among Commercially Insured Individuals at High Risk of Opioid Overdose
JAMA Network Open·2019· 69 citedOpen Access
RAD1901
Anti-Cancer Drugs·2015· 158 citedOpen Access
Effects of Abaloparatide, a Human Parathyroid Hormone-Related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis
The Journal of Clinical Endocrinology & Metabolism·2014· 255 citedOpen Access
Bone anabolic efficacy and safety of ba058, a novel analog of hPTHrP: 12-month extension data from a phase 2 clinical trial in postmenopausal women with osteoporosis
Bone Abstracts·2013· 12 cited
Transdermal delivery of BA058, a novel analog of hPTHrP (1-34), with a short wear time patch in preclinical and clinical studies
Bone Abstracts·2013
Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) <b>RAD140</b>
ACS Medicinal Chemistry Letters·2010· 70 citedOpen Access
Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs)
Bioorganic & Medicinal Chemistry Letters·2010· 19 citedOpen Access
Efficient synthesis of (2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid (4,4,4-trifluoro-OBn-d-allothreonine)
Tetrahedron Letters·2010· 8 cited
The Pairing of a Selective Estrogen Receptor Modulator, Bazedoxifene, with Conjugated Estrogens as a New Paradigm for the Treatment of Menopausal Symptoms and Osteoporosis Prevention
Endocrinology·2008· 126 citedOpen Access
Estrogen Complexes Contained in Conjugated Equine Estrogens (CEE): An Overview of Their Structure and Possible Effects on Target Tissue
Medical science symposia series·2007· 1 cited
Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells
The Journal of Steroid Biochemistry and Molecular Biology·2005· 60 cited
Bazedoxifene Acetate: A Selective Estrogen Receptor Modulator with Improved Selectivity
Endocrinology·2005· 296 cited
Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget
Journal of Biological Chemistry·2005· 76 citedOpen Access
Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget
2005
A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosis
Human Reproduction·2004· 116 cited
Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors
Endocrinology·2004· 224 citedOpen Access
Selective Estrogen Receptor Modulators
Cancer Research·2004· 398 cited
Estrogens: From Classical Endocrine Action to Tissue Selective Action
2004
Status and future direction of male contraceptive development
Current Opinion in Pharmacology·2003· 10 cited
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Frequent Co-authors

Barry S. Komm(15), Cory Teuscher(6), Jonna Frasor(3), Benita S. Katzenellenbogen(3), Yogendra P. Kharode(3), Heather A. Harris(3), Chris P. Miller(3), Gary Hattersley(3), Boris J. Cheskis(3), María C. Leiva(3), Susan A. Sundstrom(3), David T. Dennis(3), Lisa A. Hasty(3), Keith Isaacson(3), Daniel M. Sheehan(3), Jeanne M. Danes(2), Fabio Stossi(2), Peter V.N. Bodine(2), Louis O’Dea(2), Eugene R. DeSombre(2)