Ming‐Kuan Chyan

University of Washington — United States

Medicine · Health Sciences

18h-index901citations38works0.02yr avg
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Research Topics

Radiopharmaceutical Chemistry and Applications(31), Medical Imaging Techniques and Applications(15), Boron Compounds in Chemistry(12), Monoclonal and Polyclonal Antibodies Research(7), Medical Imaging and Pathology Studies(6)

Publications38 total

Investigation of the Potential for an Astatinated Version of Vizamyl for the Treatment of Alzheimer’s Disease
Nuclear Medicine and Biology·2025
Design and synthesis of astatinated benzothiazole compounds for their potential use in Targeted Alpha Therapy (TAT) strategies to treat Alzheimer's disease-associated amyloid plaques
Applied Radiation and Isotopes·2022· 9 citedOpen Access
Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo
International Journal of Molecular Sciences·2022· 8 citedOpen Access
A comparison of rhenium isolation and tungsten recovery methods from bulk tungsten targets
Nuclear Medicine and Biology·2021
Thorium chelators for targeted alpha therapy: Rapid chelation of thorium‐226
Journal of Labelled Compounds and Radiopharmaceuticals·2020· 29 citedOpen Access
Evaluation of radioiodinated protein conjugates and their potential metabolites containing lysine-urea-glutamate (LuG), PEG and closo-decaborate(2-) as models for targeting astatine-211 to metastatic prostate cancer.
Nuclear Medicine and Biology·2020· 11 citedOpen Access
Evaluation of Methods to Decrease Formation of a Higher Molecular Weight Species When211At-Labeling of Antibody-B10 Conjugates Using Chloramine-T as Oxidant
2020
Investigation of Monocarbon Carboranes as Pendant Groups for Labeling Small Molecules with Astatine-211
Journal of medical imaging and radiation sciences·2019
Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system
Scientific Reports·2019· 17 citedOpen Access
Investigation of Monocarbon Carboranes as Pendant Groups for Labeling Small Molecules with Astatine-211
Journal of medical imaging and radiation sciences·2019
cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies
PLoS ONE·2018· 35 citedOpen Access
An automated process for astatine-211 isolation from irradiated bismuth targets using a tellurium-packed column
2018· 4 cited
Evaluation of lysine-urea-glutamate derivatives that contain closo-decaborate(2-) moieties for targeting astatine-211 to metastatic prostate cancer
2014
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine
Applied Sciences·2013· 50 citedOpen Access
Antibody conjugation, characterization, and 211At labeling of a bis-maleimido-closo-decaborate(2-) derivative
2012
In vivo comparison of two anti-PSMA mAb Fab' conjugates containing branched-chain PEG derivatives with Fab' and F(ab')2
2012· 1 cited
Reagents for Astatination of Biomolecules. 6. An Intact Antibody Conjugated with a Maleimido-<i>closo</i>-Decaborate(2-) Reagent via Sulfhydryl Groups Had Considerably Higher Kidney Concentrations than the Same Antibody Conjugated with an Isothiocyanato-<i>closo</i>-Decaborate(2-) Reagent via Lysine Amines
Bioconjugate Chemistry·2012· 68 citedOpen Access
Reagents for Astatination of Biomolecules. 5. Evaluation of Hydrazone Linkers in <sup>211</sup>At- and <sup>125</sup>I-Labeled <i>closo</i>-Decaborate(2-) Conjugates of Fab′ as a Means of Decreasing Kidney Retention
Bioconjugate Chemistry·2011· 34 cited
Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting Systems with Streptavidin Mutants
Bioconjugate Chemistry·2010· 15 citedOpen Access
An initial investigation of radiolabeling with higher oxidation states of astatine-211. Evaluation of chelation with DOTA and NOTA
2010· 1 cited
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Frequent Co-authors

D. Scott Wilbur(31), Donald K. Hamlin(30), Yawen Li(12), Robert L. Vessella(7), Brian B. Kegley(6), Oliver W. Press(6), Holly M. Nguyen(5), Brenda M. Sandmaier(4), Roger Wong(4), Pradip M. Pathare(3), Ethan R. Balkin(3), Damian J. Green(3), D. Scott Wilbur(3), Tara Mastren(3), Janna E. Quinn(2), Timothy J. Wedge(2), M. Frederick Hawthorne(2), Hirohisa Nakamae(2), Erlinda B. Santos(2), Matthew A. Perry(2)