Lucien A. Aarden

Sanquin — Netherlands

Medicine · Health Sciences

48h-index11.0kcitations113works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(33), T-cell and B-cell Immunology(30), Immune Cell Function and Interaction(26), Immune Response and Inflammation(18), Immunotherapy and Immune Responses(14)

Publications113 total

Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions
Frontiers in Immunology·2017· 85 citedOpen Access
Factor VII-Activating Protease Is a Regulator of Histone Cytotoxicity
Blood·2015
FSAP‐mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE
European Journal of Immunology·2015· 12 citedOpen Access
An improved monocyte activation test using cryopreserved pooled human mononuclear cells
Innate Immunity·2015· 30 citedOpen Access
Functional Analysis of the Anti-adalimumab Response Using Patient-derived Monoclonal Antibodies
Journal of Biological Chemistry·2014· 71 citedOpen Access
Key findings towards optimising adalimumab treatment: the concentration–effect curve
Annals of the Rheumatic Diseases·2013· 208 cited
Cooperation of Factor VII–Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells
Arthritis & Rheumatology·2013· 47 cited
The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
Journal of Immunotoxicology·2013· 24 citedOpen Access
A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies
Annals of the Rheumatic Diseases·2013· 88 cited
Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation
Annals of the Rheumatic Diseases·2013· 92 cited
Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation
Annals of the Rheumatic Diseases·2012· 199 cited
IgG4 Production Against Adalimumab During Long Term Treatment of RA Patients
Journal of Clinical Immunology·2012· 66 cited
Antibodies to constant domains of therapeutic monoclonal antibodies: Anti-hinge antibodies in immunogenicity testing
Journal of Immunological Methods·2011· 90 cited
Differential effect of drug interference in immunogenicity assays
Journal of Immunological Methods·2011· 158 cited
Changes of ferritin and CRP levels in melanoma patients treated with adjuvant interferon-α (EORTC 18 952) and prognostic value on treatment outcome
Melanoma Research·2011· 13 cited
Activation of factor VII-activating protease in human inflammation: a sensor for cell death
Critical Care·2011· 54 citedOpen Access
Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody
Analytical Biochemistry·2011· 75 cited
Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study
Arthritis Research & Therapy·2010· 67 citedOpen Access
Label-free assessment of high-affinity antibody–antigen binding constants. Comparison of bioassay, SPR, and PEIA-ellipsometry
Journal of Immunological Methods·2010· 25 citedOpen Access
A novel method for the detection of antibodies to adalimumab in the presence of drug reveals “hidden” immunogenicity in rheumatoid arthritis patients
Journal of Immunological Methods·2010· 159 cited
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Frequent Co-authors

Gertjan Wolbink(13), Theo Rispens(8), M. Hart(8), Diana Wouters(7), Els R. de Groot(6), Els de Groot(5), Maarten Helle(5), Pauline A. van Schouwenburg(5), Irma Rensink(5), Michael T. Nurmohamed(4), Sacha Zeerleder(4), Bas Zwart(4), C. Krieckaert(3), Femke Stephan(3), Ingrid Bulder(3), Rob C. Aalberse(2), Steven O. Stapel(2), Paul P. Tak(2), Ben A. C. Dijkmans(2), Just P. J. Brakenhoff(2)