Donald B. Axworthy

Medicine · Health Sciences

24h-index2.0kcitations35works0.02yr avg
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Research Topics

Radiopharmaceutical Chemistry and Applications(26), Monoclonal and Polyclonal Antibodies Research(20), Lymphoma Diagnosis and Treatment(8), Medical Imaging Techniques and Applications(4), HER2/EGFR in Cancer Research(4)

Publications35 total

Correction to An <i>N</i>-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy
Bioconjugate Chemistry·2021· 2 cited
An <i>N</i>-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy
Bioconjugate Chemistry·2019· 24 citedOpen Access
Comparison of a Tetravalent Single-Chain Antibody-Streptavidin Fusion Protein and an Antibody-Streptavidin Chemical Conjugate for Pretargeted Anti-CD20 Radioimmunotherapy of B-cell Lymphomas Running Title: "Optimizing Pretargeted Radioimmunotherapy for CD20+ Lymphomas"
2016
Evaluation of CD20, CD22, and HLA-DR Targeting for Radioimmunotherapy of B-Cell Lymphomas
Cancer Research·2007· 43 cited
A Genetically Engineered Anti-CD45 Single-Chain Antibody-Streptavidin Fusion Protein for Pretargeted Radioimmunotherapy of Hematologic Malignancies
Cancer Research·2006· 64 cited
Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas
Blood·2006· 47 citedOpen Access
Comparison of Biodistributions and Therapeutic Efficacies of Pretargeted Radioimmunoconjugates Targeting the CD20, CD22, and DR Molecules on Human B Cell Lymphomas.
Blood·2005
Intraperitoneal Pretarget Radioimmunotherapy with CC49 Fusion Protein
Clinical Cancer Research·2005· 30 cited
Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.
PubMed·2005· 34 cited
Pharmacokinetics of Genetically Engineered Antibody Forms Using Positron Emission Tomography
2004Open Access
Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-<b><i>N</i></b>,<b><i>N</i></b>′,<b><i>N</i></b>″,<b><i>N</i></b>‴-Tetraacetic Acid-Biotin
Clinical Cancer Research·2004· 41 cited
Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2.
PubMed·2004· 56 cited
Biological comparison of 149Pm-, 166Ho-, and 177Lu-DOTA-biotin pretargeted by CC49 scFv-streptavidin fusion protein in xenograft-bearing nude mice
Nuclear Medicine and Biology·2004· 38 cited
In vivo evaluation of pretargeted 64Cu for tumor imaging and therapy.
PubMed·2003· 110 cited
Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas
Blood·2003· 101 cited
Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts
Proceedings of the National Academy of Sciences·2003· 105 citedOpen Access
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
PubMed·2002· 41 cited
Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the α-emitting radionuclide, bismuth 213
Blood·2002· 103 citedOpen Access
Preclinical Evaluation of a Humanized NR-LU-10 Antibody-Streptavidin Fusion Protein for Pretargeted Cancer Therapy
Cancer Biotherapy and Radiopharmaceuticals·2001· 31 cited
A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy.
PubMed·2000· 127 cited
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Frequent Co-authors

Louis Theodore(12), Yukang Lin(10), Alan R. Fritzberg(7), Oliver W. Press(7), Robert W. Mallett(6), Jody Schultz(6), John M. Pagel(6), Nathan Hedin(6), Paul L. Beaumier(5), James Sanderson(5), Thomas A. Baillie(5), Martin W. Brechbiel(5), Jorge A. Carrasquillo(5), Anastasia Pantelias(5), Hazel B. Breitz(4), Anthony J. Streeter(4), Kayhan Garmestani(4), Thomas A. Waldmann(4), D. Scott Wilbur(4), Hong-Fen Guo(4)