Leonor Pinilla

Instituto de Salud Carlos III — Spain

Medicine · Health Sciences

36h-index5.8kcitations83works26.02yr avg
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Research Topics

Hypothalamic control of reproductive hormones(46), Regulation of Appetite and Obesity(30), Ovarian function and disorders(22), Plant Reproductive Biology(17), Growth Hormone and Insulin-like Growth Factors(14)

Publications83 total

Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Nature Communications·2024· 26 citedOpen Access
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice
Nature Communications·2022· 18 citedOpen Access
Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons
Metabolism·2022· 10 citedOpen Access
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty
Cell Metabolism·2020· 83 citedOpen Access
AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin
Cells·2020· 9 citedOpen Access
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
PLoS Biology·2019· 74 citedOpen Access
Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis
Metabolism·2019· 46 cited
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
Endocrine Abstracts·2019Open Access
Conditional ablation of AMP-Activated Protein Kinase (AMPK) in GnRH neurons reveals specific roles in reproductive and metabolic homeostasis
Endocrine Abstracts·2019
Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling
Proceedings of the National Academy of Sciences·2018· 79 citedOpen Access
Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice
Metabolism·2018· 22 cited
Reproductive and metabolic consequences of AMP-Activated Protein Kinase (AMPK) ablation in GnRH neurons
Endocrine Abstracts·2018
Novel role of central ceramide signaling in mediating obesity-induced precocious puberty
Endocrine Abstracts·2018
Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways
Endocrinology·2017· 49 citedOpen Access
Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Molecular Metabolism·2016· 167 citedOpen Access
Hypothalamic GRK2, via GPR54, modulates puberty onset
Endocrine Abstracts·2016Open Access
Intergenerational influence of paternal obesity on metabolic and reproductive health of the offspring: male-preferential impact and potential involvement of Kiss1-mediated pathways
Endocrine Abstracts·2016Open Access
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity
Scientific Reports·2016· 74 citedOpen Access
RF9 Acts as a KISS1R Agonist In Vivo and In Vitro
Endocrinology·2015· 34 citedOpen Access
Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion
Endocrinology·2015· 28 citedOpen Access
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Frequent Co-authors

Manuel Tena‐Sempere(49), E. Aguilar(25), Francisco Ruíz-Pino(21), Juan Roa(18), Juan M. Castellano(16), Carlos Diéguez(15), David García-Galiano(13), Silvia León(13), Rafael Pineda(12), Miguel A. Sánchez-Garrido(12), María Manfredi-Lozano(12), Francisco Gaytán(12), María J. Vázquez(12), Antonio Romero‐Ruíz(10), Víctor M. Navarro(9), Violeta Heras(9), Alexia Barroso(7), Lucas Cerrillos González(6), Inmaculada Velasco(6), Rafael Fernández(5)