Roland P.‐T. Chung

Monash University — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index506citations27works0.02yr avg
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Research Topics

Aldose Reductase and Taurine(15), Diet, Metabolism, and Disease(5), Biochemical effects in animals(5), Prenatal Substance Exposure Effects(4), Pancreatic function and diabetes(3)

Publications27 total

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorganic & Medicinal Chemistry Letters·2010· 8 cited
Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor
European Journal of Medicinal Chemistry·2009· 32 citedOpen Access
Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14)
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2009· 3 citedOpen Access
Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase
Bioorganic & Medicinal Chemistry·2008· 24 citedOpen Access
Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Archives of Biochemistry and Biophysics·2008· 14 cited
A Salicylic Acid-Based Analogue Discovered from Virtual Screening as a Potent Inhibitor of Human 20α-Hydroxysteroid Dehydrogenase
Medicinal Chemistry·2007· 33 cited
Structure of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2007· 7 citedOpen Access
Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site‐directed mutagenesis
Proteins Structure Function and Bioinformatics·2007· 12 cited
Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases:  Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat Complex
Journal of Medicinal Chemistry·2005· 55 cited
Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat:  Implications for Inhibitor Binding and Selectivity
Journal of Medicinal Chemistry·2005· 73 citedOpen Access
Crystal structure of human L‐xylulose reductase holoenzyme: Probing the role of Asn107 with site‐directed mutagenesis
Proteins Structure Function and Bioinformatics·2004· 24 cited
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase
Acta Crystallographica Section D Biological Crystallography·2003· 3 cited
Structure of human aldose reductase holoenzyme in complex with Statil: An approach to structure‐based inhibitor design of the enzyme
Proteins Structure Function and Bioinformatics·2002· 33 cited
Crystallization and preliminary crystallographic analysis of human L-xylulose reductase
Acta Crystallographica Section D Biological Crystallography·2002· 6 cited
Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase
Acta Crystallographica Section D Biological Crystallography·2001· 1 cited
Crystallization and preliminary x-ray analysis of porcine aldehyde reductase in complex with coenzyme and quercetin
Protein and Peptide Letters·2000
Aldose and aldehyde reductases: Correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site
Proteins Structure Function and Bioinformatics·2000· 26 cited
Purification and characterization of basic proteins with in vitro antifungal activity from seeds of cotton, Gossypium hirsutum
Plant Science·1997· 35 cited
Radical-Induced Decomposition of Dimethyl-<i>N</i>-(2-Cyano-2-Propyl)Ketenimine
Journal of Macromolecular Science Part A·1994· 2 cited
Radical-Induced Decomposition of Dimethyl-N-(2-Cyan0-2-Pr0Pyl)Ketenimine
Journal of Macromolecular Science Part A·1994
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Frequent Co-authors

Ossama El‐Kabbani(16), Vincenzo Carbone(8), Akira Hara(8), Satoshi Endo(7), Connie Darmanin(4), A. Podjarny(4), Trevor J. Broxton(4), Urmi Dhagat(3), Akira Hara(3), Noriyuki Usami(3), David H. Solomon(3), Mitsuru Oka(2), A. Mitschler(2), Clemens Schulze‐Briese(2), John Christie(2), Gregory M. Neumann(2), Gideon M. Polya(2), Paul A. Ramsland(2), Toshiyuki Matsunaga(2), Syuhei Ishikura(2)