S P Spielberg

Riley Hospital for Children — United States

Medicine · Health Sciences

15h-index2.3kcitations23works0.02yr avg
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Research Topics

Pharmacological Effects and Toxicity Studies(5), Asthma and respiratory diseases(3), Pharmacogenetics and Drug Metabolism(3), Metabolism and Genetic Disorders(3), Drug-Induced Adverse Reactions(3)

Publications23 total

Altered Phagocytosis and Microtubule Function in Leukocytes from a Patient with Severe Glutathione Synthase Deficiency (5-Oxoprolinuria)
Monographs in human genetics·2015· 4 cited
Patients with Delayed-Onset Sulfonamide Hypersensitivity Reactions Have Antibodies Recognizing Endoplasmic Reticulum Luminal Proteins
Journal of Pharmacology and Experimental Therapeutics·1997· 46 cited
Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis.
PubMed·1996· 152 cited
In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity.
Journal of Pharmacology and Experimental Therapeutics·1995· 31 cited
N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.
Drug Metabolism and Disposition·1995· 164 cited
Increased cosedimentation of cytosolic glutathione S-transferases with microsomal fractions prepared from frozen rat liver.
Drug Metabolism and Disposition·1994· 1 cited
Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Journal of Pharmacology and Experimental Therapeutics·1992· 92 cited
Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes.
Journal of Pharmacology and Experimental Therapeutics·1991· 71 cited
Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
Drug Metabolism and Disposition·1991· 153 cited
Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs.
Molecular Pharmacology·1990· 107 cited
Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine.
Drug Metabolism and Disposition·1990· 66 cited
Fluorescence-based viability assay for studies of reactive drug intermediates
Analytical Biochemistry·1989· 31 cited
Diagnosis of Sulfonamide Hypersensitivity Reactions by In-Vitro "Rechallenge" with Hydroxylamine Metabolites
Annals of Internal Medicine·1989· 240 cited
Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
Journal of Clinical Investigation·1988· 689 citedOpen Access
Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Journal of Pharmacology and Experimental Therapeutics·1988· 14 cited
Metabolism of leukotriene A4 into C4 by human platelets.
PubMed·1987· 2 cited
Human genetic defect in leukotriene C4 synthesis
Biochemical and Biophysical Research Communications·1986· 9 cited
GENETIC PREDISPOSITION TO PHENYTOIN-INDUCED BIRTH DEFECTS
The Lancet·1985· 221 cited
417 PHARMACOGENETIC PREDISPOSITION TO PHENYTOIN-INDUCED BIRTH DEFECTS
Pediatric Research·1985· 5 citedOpen Access
Calcium-binding proteins from squid optic lobes
Cell Calcium·1984· 2 cited
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Frequent Co-authors

Alastair E. Cribb(9), J. Steven Leeder(5), Marissa A. Miller(3), Neil H. Shear(2), Jack Uetrecht(2), G P Griffin(2), Marcia A. Miller(2), Denis M. Grant(2), J. W. Head(2), Benjamin Kaminer(2), C.R. Pace-Asciak(2), J D Schulman(2), Michael Rieder(1), Mary Cannon(1), SusanM. Strickler(1), M. Piquette Miller(1), Eva Andermann(1), LindaV. Dansky(1), Marie‐Hélène Seni(1), John Hill(1)