Karen Block

VA Office of Research and Development — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index5.6kcitations66works0.02yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(19), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(17), Nitric Oxide and Endothelin Effects(14), Advanced Glycation End Products research(8), Chronic Kidney Disease and Diabetes(6)

Publications66 total

Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma
Translational research·2020· 13 citedOpen Access
NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
Nature Communications·2017· 207 citedOpen Access
mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes
Antioxidants and Redox Signaling·2016· 66 citedOpen Access
Renal Carcinogenesis, Tumor Heterogeneity, and Reactive Oxygen Species: Tactics Evolved
Antioxidants and Redox Signaling·2016· 16 cited
Impact of Mechanical Harvesting and Optical Berry Sorting on Grape and Wine Composition
American Journal of Enology and Viticulture·2016· 32 cited
HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice
Diabetes·2016· 119 citedOpen Access
The impact of machine harvesting with and without optical berry sorting on Pinot Noir wine composition and quality
Wine & viticulture journal·2016
Activation of AMP-Activated Protein Kinase Prevents TGF-β1–Induced Epithelial-Mesenchymal Transition and Myofibroblast Activation
American Journal Of Pathology·2015· 104 citedOpen Access
Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes
American Journal of Physiology-Renal Physiology·2015· 178 citedOpen Access
Abstract LB-131: Elevated (L) -2-hydroxyglutarate promotes loss of 5-hydroxymethylcytosine in clear cell renal cancer
Cancer Research·2014
<scp>l</scp> -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Cancer Discovery·2014· 289 citedOpen Access
The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling
Journal of Biological Chemistry·2014· 61 citedOpen Access
A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody
2014
Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II
Journal of Biological Chemistry·2013· 120 citedOpen Access
Nox as a target for diabetic complications
Clinical Science·2013· 119 cited
Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury
Diabetes·2013· 133 citedOpen Access
460 CONCURRENT METABOLIC AND TRANSCRIPTOMIC ANALYSIS OF CLEAR CELL RENAL CANCER
The Journal of Urology·2013
Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?
Free Radical Biology and Medicine·2013· 131 citedOpen Access
In search of solutions to grapevine trunk diseases through “crowd-sourced” science
Frontiers in Plant Science·2013· 4 citedOpen Access
Aiding and abetting roles of NOX oxidases in cellular transformation
Nature reviews. Cancer·2012· 287 citedOpen Access
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Frequent Co-authors

Yves Gorin(23), Hanna E. Abboud(17), Assaad A. Eid(10), Jeffrey L. Barnes(8), Karthigayan Shanmugasundaram(8), Sunil Sudarshan(7), B. K. Nayak(6), Goutam Ghosh Choudhury(5), Dipen J. Parekh(5), Carolina B. Livi(4), William E. Friedrichs(4), Goutam Ghosh-Choudhury(3), David New(3), P. Renée Yew(3), Bhesh Bhandari(2), Brent Wagner(2), Eun‐Hee Shim(2), Rita Maalouf(2), A Kardana(2), Peter Igarashi(2)