William C. Raschke

Virogenomics BioDevelopment (United States) — United States

Medicine · Health Sciences

28h-index4.0kcitations61works0.72yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(20), Immune Cell Function and Interaction(16), T-cell and B-cell Immunology(14), Glycosylation and Glycoproteins Research(11), Virus-based gene therapy research(6)

Publications61 total

Safety, Pharmacokinetics, and Cardiodynamics of CMS121, a Novel Small Molecule Fisetin Derivative with Neuroprotective Properties, in Phase 1 Healthy Adult Volunteers
2025Open Access
CMS121, a Novel Drug Candidate for the Treatment of Alzheimer’s Disease and Age-Related Dementia
Advances in Alzheimer's disease·2024
CMS121, a Novel Drug Candidate for the Treatment of Alzheimer’s Disease and Age-Related Dementia
Journal of Alzheimer s Disease·2024· 2 cited
Long-term correction of hemophilia A mice following lentiviral mediated delivery of an optimized canine factor VIII gene
Gene Therapy·2017· 17 citedOpen Access
Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages (subtractive hybridization/lymphocyte differentiation/regulated gene expression/T200 mutant)
2016
An extracatalytic function of CD45 in B cells is mediated by CD22
Proceedings of the National Academy of Sciences·2015· 37 citedOpen Access
Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival
Proceedings of the National Academy of Sciences·2011· 55 citedOpen Access
Titration of CD45 expression regulates sequential tolerance checkpoints during B cell development (45.2)
The Journal of Immunology·2011
CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development
Immunity·2010· 84 citedOpen Access
Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection
Cell Host & Microbe·2009· 20 citedOpen Access
An allelic series of CD45 dosages uncouples basal and inducible TCR signaling during thymic development (84.13)
The Journal of Immunology·2009
Reduced Expression of CD45 Protein-tyrosine Phosphatase Provides Protection against Anthrax Pathogenesis
Journal of Biological Chemistry·2009· 27 citedOpen Access
A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency
Blood·2003· 16 citedOpen Access
The Role of Intron Sequences in High Level Expression from CD45 cDNA Constructs
Journal of Biological Chemistry·2001· 26 citedOpen Access
Expression of CD45 isoforms lacking exons 7, 8 and 10
Molecular Immunology·1998· 20 cited
Murine mast cells and monocytes express distinctive sets of CD45 isoforms
Molecular Immunology·1997· 10 cited
Inducible expression of a heterologous protein in Hansenula polymorpha using the alcohol oxidase 1 promoter of Pichia pastoris
Gene·1996· 35 cited
Enhanced Plasmin Inhibition by a Reactive Center Lysine Mutant of the Kunitz-type Protease Inhibitor Domain of the Amyloid β-Protein Precursor
Journal of Biological Chemistry·1995· 21 citedOpen Access
Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid β-protein precursor-like protein-2
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·1994· 39 citedOpen Access
Recent Advances in the Expression of Foreign Genes in Pichia pastoris
Nature Biotechnology·1993· 912 cited
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Frequent Co-authors

Clinton E. Ballou(6), Stephen M. Baird(5), Elizabeth L. Virts(4), Diana S. Barritt(4), Julie Zikherman(3), Arthur Weiss(3), Melvin Cohn(3), Steven L. Wagner(3), Robert S. Siegel(3), James M. Cregg(2), Thomas S. Vedvick(2), P Ralph(2), Ilona Nakoinz(2), Marilyn R. Kehry(2), S. J. Ewald(2), R. Douglas(2), Carol Hopkins Sibley(2), Leroy Hood(2), Kenneth A. Kern(2), Kristin Doan(2)