Gu‐Gang Chang

National Yang Ming Chiao Tung University — Taiwan

Materials Science · Physical Sciences

32h-index3.4kcitations105works0.02yr avg
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Research Topics

Enzyme Structure and Function(27), Protein Structure and Dynamics(16), Drug Transport and Resistance Mechanisms(13), Protein Interaction Studies and Fluorescence Analysis(12), Alkaline Phosphatase Research Studies(11)

Publications105 total

Applications of analytical ultracentrifugation to protein size-and-shape distribution and structure-and-function analyses
Methods·2010· 11 citedOpen Access
Essential covalent linkage between the chymotrypsin-like domain and the extra domain of the SARS-CoV main protease
The Journal of Biochemistry·2010· 18 citedOpen Access
Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
Biophysical Journal·2010· 150 citedOpen Access
Quaternary Structure of the SARS Coronavirus Main Protease
2009· 32 citedOpen Access
Thiopurine Analogue Inhibitors of Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease, a Deubiquitinating and deISGylating Enzyme
Antiviral chemistry & chemotherapy·2009· 84 citedOpen Access
The roles of Tyr91 and Lys162 in general acid–base catalysis in the pigeon NADP+-dependent malic enzyme
Biochemical Journal·2008· 6 cited
Correlation between dissociation and catalysis of SARS-CoV main protease
Archives of Biochemistry and Biophysics·2008· 60 citedOpen Access
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus
Biochemical Pharmacology·2008· 106 citedOpen Access
Metal Ions Stabilize a Dimeric Molten Globule State between the Open and Closed Forms of Malic Enzyme
Biophysical Journal·2007· 9 citedOpen Access
Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoforms
Proteins Structure Function and Bioinformatics·2007· 3 cited
Crystal Structure of Murine CstF-77: Dimeric Association and Implications for Polyadenylation of mRNA Precursors
Molecular Cell·2007· 88 citedOpen Access
Reversible Unfolding of the Severe Acute Respiratory Syndrome Coronavirus Main Protease in Guanidinium Chloride
Biophysical Journal·2006· 40 citedOpen Access
Investigation of the Dimer Interface and Substrate Specificity of Prolyl Dipeptidase DPP8
Journal of Biological Chemistry·2006· 40 citedOpen Access
Critical roles of conserved carboxylic acid residues in pigeon cytosolic NADP<sup>+</sup>‐dependent malic enzyme
FEBS Journal·2006· 2 cited
Determinants of the Dual Cofactor Specificity and Substrate Cooperativity of the Human Mitochondrial NAD(P)+-dependent Malic Enzyme
Journal of Biological Chemistry·2006· 43 citedOpen Access
Is Dimerization Required for the Catalytic Activity of Bacterial Biotin Carboxylase?
Molecular Cell·2006· 35 citedOpen Access
Critical role of tryptophanyl residues in the conformational stability of goose δ-crystallin
Experimental Eye Research·2006· 3 cited
Structural and Functional Variations in Human Apolipoprotein E3 and E4
Journal of Biological Chemistry·2006· 46 citedOpen Access
Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme)
Biochemical Journal·2005· 31 citedOpen Access
Functional Roles of ATP-Binding Residues in the Catalytic Site of Human Mitochondrial NAD(P)<sup>+</sup>-Dependent Malic Enzyme
Biochemistry·2005· 22 cited
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Frequent Co-authors

Chi‐Yuan Chou(13), Wei‐Yuan Chou(8), Hui‐Chih Hung(8), Liang Tong(6), Ter-Mei Huang(6), Hui-Chuan Chang(5), Yu‐San Han(3), Wen-Chi Hsu(3), Ching-Chun Lin(3), Ming‐Shi Shiao(3), Lai‐Chen Tsai(3), Mei‐Whey Hung(3), Tsu‐Chung Chang(3), Robert Y. Hsu(3), Guang‐Yaw Liu(3), Shiao-Shek Tang(3), Po‐Huang Liang(2), Hong-Jen Lee(2), Chia‐Hui Chien(2), Yuan‐Shou Chen(2)