P. Contreras

Hospital Clínico de la Universidad de Chile — Chile

Neuroscience · Life Sciences

16h-index1.1kcitations31works3.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(8), Neuroscience and Neuropharmacology Research(7), Receptor Mechanisms and Signaling(5), Pharmacological Receptor Mechanisms and Effects(5), Cell death mechanisms and regulation(4)

Publications31 total

Nicotinamide Prevents the Plasticity Impairments and the Cognitive Dysfunction Caused by Bone Fracture in Older Mice
The Journals of Gerontology Series A·2025· 3 citedOpen Access
Correlation between the concentration and morphology of copper microparticles and their biocidal effect on paper sheets
Cellulose·2020· 3 cited
Carcinogenicity assessment of the pan-caspase inhibitor, emricasan, in Tg.rasH2 mice
Regulatory Toxicology and Pharmacology·2015· 8 cited
P0396 : Emricasan, a potent pan caspase inhibitor, rapidly reduces caspase activity and biomarkers of apoptosis in patients with hepatic impairment but not in healthy volunteers: Implications for safety, selectivity and mechanism of action
Journal of Hepatology·2015Open Access
292 PAN-CASPASE INHIBITION PROTECTS AGAINST FIBROTIC NASH INDUCED BY CHOLINE DEFICIENT AMINO ACID DEFINED DIET (CDAA)
Journal of Hepatology·2013Open Access
Potential Utility of rhIGF‐1 in Neuromuscular and/or Degenerative Disease
Novartis Foundation symposium·2007· 15 cited
874 IDN-6556, the first anti-apoptotic caspase inhibitor in clinical trials: tissue distribution and pharmacokinetics
Hepatology·2003· 2 cited
871 IDN-6556, the first anti-apoptotic caspase inhibitor: preclinical efficacy and safety
Hepatology·2003· 2 cited
Characterization of the Caspase Inhibitor IDN-1965 in a Model of Apoptosis-Associated Liver Injury
Journal of Pharmacology and Experimental Therapeutics·2001· 42 cited
Acute gastrointestinal effects of graded levels of copper in drinking water.
Environmental Health Perspectives·1999· 138 citedOpen Access
Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine
Neuroscience·1998· 99 cited
Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Disease
1998· 2 cited
Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury
Experimental Neurology·1997· 186 citedOpen Access
Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice.
Journal of Pharmacology and Experimental Therapeutics·1995· 57 cited
Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation ofN-methyl-d-aspartate (NMDA) receptor complex-mediated events by sigma ligands
Brain Research·1991· 32 cited
(+) 3-[3-Hydroxyphenyl-n-(1-propyl) piperidine] selectively differentiates effects of sigma ligands on neurochemical pathways modulated by sigma receptors: Evidence for subtypes, in vivo
Neuropharmacology·1991· 26 cited
Clozapine attenuates N-methyl-d-aspartate receptor complex-mediated responses in vivo: tentative evidence for a functional modulation by a noradrenergic mechanism
Neuropharmacology·1991· 73 cited
Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil
Brain Research·1991· 49 cited
Opipramol, a potent sigma ligand, is an anti-ischemic agent: Neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements
Neuropharmacology·1990· 44 cited
Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo
Neuropharmacology·1990· 27 cited
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Frequent Co-authors

Tadimeti S. Rao(5), Satish Iyengar(5), Julie A. Cler(4), Steve J. Mick(4), R Later(4), Nancy M. Gray(3), Paul L. Wood(3), Niel C. Hoglen(3), Kyle Valentino(3), A.M. Freyria(3), A.E. Takemori(2), Mark R. Emmett(2), Patrick B. Wood(2), Jeffry L. Vaught(2), Thomas N. Chase(2), Kenner C. Rice(2), Thomas L. O’Donohue(2), Diane M. Ragan(2), Thomas H. Lanthorn(2), Brad Hirakawa(2)