Antonı́n Holý

Czech Academy of Sciences — Czech Republic

Medicine · Health Sciences

53h-index15.0kcitations809works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(268), Biochemical and Molecular Research(227), Synthesis and Characterization of Heterocyclic Compounds(172), DNA and Nucleic Acid Chemistry(161), Carbohydrate Chemistry and Synthesis(84)

Publications809 total

Acid–base properties of an antivirally active acyclic nucleoside phosphonate: (<i>S</i>)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA)
New Journal of Chemistry·2022· 4 citedOpen Access
Metal Ion‐Coordinating Properties in Aqueous Solutions of the Antivirally Active Nucleotide Analogue (<i>S</i>)‐9‐[3‐Hydroxy‐2‐(phosphonomethoxy)propyl]adenine (HPMPA) – Quantification of Complex Isomeric Equilibria
European Journal of Inorganic Chemistry·2019· 4 citedOpen Access
Intramolecular π-stacks in mixed-ligand copper(II) complexes formed by heteroaromatic amines and antivirally active acyclic nucleotide analogs carrying a hydroxy-2-(phosphonomethoxy)propyl residue<sup>‡</sup>
Journal of Coordination Chemistry·2018· 4 cited
Metal-ion binding properties of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir). A nucleotide analogue with activity against DNA viruses
Inorganica Chimica Acta·2017· 5 cited
Investigation of the acid-base and electromigration properties of 5‐azacytosine derivatives using capillary electrophoresis and density functional theory calculations
Journal of Chromatography A·2016· 13 cited
Estimation of apparent binding constant of complexes of selected acyclic nucleoside phosphonates with β‐cyclodextrin by affinity capillary electrophoresis
Electrophoresis·2015· 41 cited
Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the anticancer and antivirally active 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG). A comparison with related acyclic nucleotide analogues
Polyhedron·2015· 6 citedOpen Access
Influence of Acyclic Nucleoside Phosphonate Antivirals on Gene Expression of Chemokine Receptors CCR5 and CXCR4
Folia Biologica·2015· 2 citedOpen Access
Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production
Medicinal Chemistry Research·2014· 10 cited
5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production
Medicinal Chemistry Research·2014· 24 citedOpen Access
Solution properties of metal ion complexes formed with the antiviral and cytostatic nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-amino-6-dimethylaminopurine (PME2A6DMAP)
Canadian Journal of Chemistry·2014· 6 cited
A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity
PLoS Pathogens·2013· 22 citedOpen Access
The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases
European Journal of Medicinal Chemistry·2013· 21 citedOpen Access
Extent of Intramolecular π Stacks in Aqueous Solution in Mixed‐Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and 1‐[2‐(Phosphonomethoxy)ethyl]cytosine (PMEC), a Relative of Antivirally Active Acyclic Nucleotide Analogues (Part 72)<sup>[1, 2]</sup>
Zeitschrift für anorganische und allgemeine Chemie·2013· 4 cited
Extent of Intramolecular<i>π</i>‐Stacks in Aqueous Solution in Mixed‐Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2‐Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA)
Chemistry & Biodiversity·2012· 13 citedOpen Access
Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening
Bioorganic & Medicinal Chemistry Letters·2012· 7 cited
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli
Bioorganic & Medicinal Chemistry·2012· 9 cited
Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis
Plant Cell Tissue and Organ Culture (PCTOC)·2012· 4 cited
Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: In vitro study on MDBK cell and BHV-1 virus
Journal of Controlled Release·2012· 13 cited
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
PubMed·2012· 4 cited
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Frequent Co-authors

Erik De Clercq(30), Jan Balzarini(17), Ivan Rosenberg(12), Robert Snoeck(12), Lieve Naesens(10), Graciela Andreï(9), Ivan Votruba(8), Milena Masojı́dková(8), Hana Dvořáková(7), Dana Hocková(5), Takashi Sakuma(3), Masanori Baba(3), Rudi Pauwels(3), Jindřich Jindřich(3), Johan Neyts(3), Dominique Schols(2), Piet Herdewijn(2), David G. Johns(2), Michal Hocek(2), Aleš Merta(2)