César Aguirre

The University of Osaka — Japan

Medicine · Health Sciences

10h-index359citations43works2.42yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(17), Alzheimer's disease research and treatments(9), Hematopoietic Stem Cell Transplantation(6), Neurological disorders and treatments(4), Acute Myeloid Leukemia Research(3)

Publications43 total

A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction
Neuroscience Research·2026Open Access
Conformational Switch in the Alpha‐Synuclein C‐Terminal Domain Directs Its Fibril Polymorphs
Chemistry - A European Journal·2025· 2 citedOpen Access
Therapeutic effect of TTR siRNA on hereditary transthyretin amyloidosis (ATTRv) nephropathy
Amyloid·2025
Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation
Neurochemistry International·2024· 1 citedOpen Access
Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Pharmacology Research & Perspectives·2024· 9 citedOpen Access
Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles
Proceedings of the National Academy of Sciences·2023· 50 citedOpen Access
Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane
npj Parkinson s Disease·2023· 18 citedOpen Access
Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor
ACS Sensors·2023· 8 cited
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism
Acta Neuropathologica·2023· 24 citedOpen Access
Is VTD the Best First Line Therapy for Multiple Myeloma in an Environment with Limited Resources? an Analysis of Outcomes and Costs
Transplantation and Cellular Therapy·2023Open Access
Effectiveness of Autologous Transplantation to Achieve Prolonged Remission in Refractory/Relapsed Classical Hodgkin’s Lymphoma, a 10-Year Experience in an Outpatient Transplant Center with Limited Resources
Transplantation and Cellular Therapy·2023Open Access
Extracellular transportation of α-synuclein by HLA class II molecules
Biochemical and Biophysical Research Communications·2022· 6 cited
Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Nature Communications·2022· 26 citedOpen Access
Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs
2022· 2 citedOpen Access
Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
2022· 2 citedOpen Access
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis
European Journal of Neurology·2022· 7 citedOpen Access
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease
Scientific Reports·2022· 34 citedOpen Access
Serum asymmetric dimethyl arginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis
2021Open Access
Polyphenol‐solubility alters amyloid fibril formation of α‐synuclein
Protein Science·2021· 20 citedOpen Access
Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners
Journal of Biological Chemistry·2021· 14 citedOpen Access
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Frequent Co-authors

Kensuke Ikenaka(22), Hideki Mochizuki(20), Keita Kakuda(11), Kousuke Baba(11), Seiichi Nagano(11), Yasuyoshi Kimura(10), Yuji Goto(10), K. Yamaguchi(9), David Gómez‐Almaguer(9), Chi‐Jing Choong(7), Yoshitaka Nagai(7), Masatomo So(7), Kichitaro Nakajima(7), Perla R. Colunga Pedraza(7), Luz del Carmen Tarín Arzaga(7), Olga Cantu Rodriguez(7), David Gómez Almaguer(7), Junko Doi(6), Takahiro Ajiki(5), Hirotsugu Ogi(5)