Anne‐Marie Michon

GlaxoSmithKline (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index11.5kcitations47works0.02yr avg
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Research Topics

Protein Degradation and Inhibitors(26), Multiple Myeloma Research and Treatments(12), Advanced biosensing and bioanalysis techniques(10), Genomics and Chromatin Dynamics(9), Ubiquitin and proteasome pathways(8)

Publications47 total

Identification of a Series of <i>N</i>-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins
Journal of Medicinal Chemistry·2021· 22 citedOpen Access
CCDC 2001550: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
Journal of Medicinal Chemistry·2020· 63 citedOpen Access
Design and Synthesis of a Highly Selective and <i>In Vivo</i>-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
Journal of Medicinal Chemistry·2020· 52 citedOpen Access
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family
ACS Medicinal Chemistry Letters·2020· 32 citedOpen Access
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains
Journal of Medicinal Chemistry·2020· 34 citedOpen Access
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Science·2020· 412 citedOpen Access
Biological plasticity rescues target activity in CRISPR knock outs
Nature Methods·2019· 231 cited
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification
Journal of Medicinal Chemistry·2019· 34 citedOpen Access
Biological Plasticity Rescues Target Activity in CRISPR Knockouts
2019· 15 citedOpen Access
BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Epigenetics & Chromatin·2019· 46 citedOpen Access
MOESM12 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM6 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM11 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM9 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM4 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM7 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM8 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
MOESM1 of BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Figshare·2019Open Access
Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors
Journal of Medicinal Chemistry·2018· 26 citedOpen Access
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Frequent Co-authors

Paola Grandi(31), Rab K. Prinjha(26), Gerard Drewes(17), Chun‐wa Chung(17), Paul Bamborough(16), Emmanuel H. Demont(14), Darren J. Mitchell(13), Robert J. Watson(12), Enid Y.N. Lam(10), M. Petretich(10), Mark A. Dawson(10), Laurie Gordon(9), Pierre Khoueiry(9), Aoife Ward(9), Daniel F. Simola(9), Eileen E. M. Furlong(9), Vladimı́r Beneš(9), Robert J. Sheppard(8), Inmaculada Rioja(7), Matthew Lindon(7)