Rajam S. Mani

University of Alberta — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.8kcitations81works0.02yr avg
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Research Topics

DNA Repair Mechanisms(23), S100 Proteins and Annexins(18), Computational Drug Discovery Methods(13), DNA and Nucleic Acid Chemistry(10), Cancer therapeutics and mechanisms(10)

Publications81 total

F2,6BP restores mitochondrial genome integrity in Huntington’s disease
Journal of Biological Chemistry·2026Open Access
Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor
Scientific Reports·2022· 14 citedOpen Access
Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains
Frontiers in Oncology·2022· 16 citedOpen Access
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3′-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer
Journal of Controlled Release·2021· 17 citedOpen Access
Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase: IMPLICATIONS FOR NONHOMOLOGOUS END JOINING
UNC Libraries·2020· 2 citedOpen Access
Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway
European Journal of Medicinal Chemistry·2020· 12 citedOpen Access
Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF
Journal of Medicinal Chemistry·2019· 29 citedOpen Access
Domain analysis of PNKP–XRCC1 interactions: Influence of genetic variants of XRCC1
Journal of Biological Chemistry·2018· 21 citedOpen Access
Clinical dysregulation of DNA repair by the polynucleotide kinase/phosphatase-XRCC4-DNA ligase IV in neurological disease
Annals of Oncology·2017Open Access
The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair
Journal of Biological Chemistry·2017· 19 citedOpen Access
Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex
Nucleic Acids Research·2017· 51 citedOpen Access
Efforts toward Identifying the Binding Site of an Inhibitor of Human Polynucleotide Kinase/Phosphatase using an Imidopiperidine Inhibitor by Photoaffinity Labelling
URSCA Proceedings·2015
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage
Nucleic Acids Research·2011· 71 citedOpen Access
XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
Journal of Biological Chemistry·2011· 171 citedOpen Access
Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair
Trends in Biochemical Sciences·2011· 197 citedOpen Access
Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase
Journal of Biological Chemistry·2010· 63 citedOpen Access
Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase
Journal of Biological Chemistry·2009· 47 citedOpen Access
Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1
Nucleic Acids Research·2009· 27 citedOpen Access
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase
Nucleic Acids Research·2009· 54 citedOpen Access
Polynucleotide Kinase as a Potential Target for Enhancing Cytotoxicity by Ionizing Radiation and Topoisomerase I Inhibitors
Anti-Cancer Agents in Medicinal Chemistry·2008· 36 citedOpen Access
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Frequent Co-authors

Michael Weinfeld(21), Cyril M. Kay(14), Feridoun Karimi‐Busheri(11), C.M. Kay(10), Carol E. Cass(9), Mesfin Fanta(8), J. N. Mark Glover(7), Yaping Yu(4), Shujuan Fang(4), Susan P. Lees‐Miller(4), William D. McCubbin(4), Nina Bernstein(3), Ismail Abdou(3), Michal Hammel(3), John A. Tainer(3), James D. Young(3), Stephen A. Baldwin(3), Keith W. Caldecott(3), Ahmed H. Elmenoufy(3), Francesco Gentile(3)