Darren Smart

GlaxoSmithKline (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.0kcitations51works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(16), Neuropeptides and Animal Physiology(13), Sleep and Wakefulness Research(13), Ion Channels and Receptors(12), Cannabis and Cannabinoid Research(10)

Publications51 total

Measurement of Inositol(1,4,5)Trisphosphate Using a Stereospecific Radioreceptor Mass Assay
Methods in molecular biology·2012
Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor
Journal of Pharmacology and Experimental Therapeutics·2007· 103 cited
Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
Bioorganic & Medicinal Chemistry Letters·2006· 132 citedOpen Access
Measurement of Inositol(1,4,5)Trisphosphate Using a Stereospecific Radioreceptor Mass Assay
Humana Press eBooks·2005· 3 cited
Cannabinoid CB<sub>2</sub> receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
European Journal of Neuroscience·2004· 160 cited
Evidence for biological effects of exogenous LPA on rat primary afferent and spinal cord neurons
Brain Research·2004· 26 cited
TRPV1 and CB<sub>1</sub> receptor‐mediated effects of the endovanilloid/endocannabinoid <i>N</i>‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat
European Journal of Neuroscience·2004· 80 cited
Discovery of small molecule antagonists of TRPV1
Bioorganic & Medicinal Chemistry Letters·2004· 65 citedOpen Access
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed <i>via</i> a non‐CB<sub>1</sub>/CB<sub>2</sub> G<sub>i/o</sub> linked receptor
British Journal of Pharmacology·2004· 33 citedOpen Access
Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats
European Journal of Pharmacology·2004· 26 cited
Measurement of Inositol(1,4,5)trisphosphate Using a Stereospecific Radioreceptor Mass Assay
Humana Press eBooks·2003
Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid
Biochemical Pharmacology·2003· 47 citedOpen Access
Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats
Brain Research·2003· 51 cited
The Effects of Local and Intravenous Anesthetics on Recombinant Rat VR1 Vanilloid Receptors
Anesthesia & Analgesia·2003· 32 cited
Lack of an interaction between orexinergic and opioid/nociceptinergic systems in rat cerebrocortical slices
Neuroscience Letters·2003· 1 cited
N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity
Bioorganic & Medicinal Chemistry·2003· 13 cited
Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5‐trisphosphate‐sensitive stores
British Journal of Pharmacology·2003· 68 citedOpen Access
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors
Biochemical Pharmacology·2002· 24 citedOpen Access
Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: Roles in regulation of cardiovascular function
Life Sciences·2002· 62 cited
‘Entourage’ effects of <i>N</i>‐acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide‐induced vanilloid receptor activation and upon anandamide metabolism
British Journal of Pharmacology·2002· 137 citedOpen Access
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Frequent Co-authors

David G. Lambert(15), Jeffrey C. Jerman(13), Stephen Brough(10), John B. Davis(8), David A. Kendall(7), Alexander T. McKnight(5), Vera Ralevic(5), Andrew D. Randall(4), Martin J. Gunthorpe(4), David J. Rowbotham(4), Victoria Chapman(3), Séverine Vandevoorde(3), Didier M. Lambert(3), Christopher J. Fowler(3), Harshad K. Rami(3), Mervyn Thompson(3), Beverley Nicol(3), Julie Egerton(3), Derek N. Middlemiss(3), P Millns(3)