Lusong Luo

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index872citations24works0.02yr avg
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Research Topics

Protein Structure and Dynamics(4), Computational Drug Discovery Methods(4), Microbial Natural Products and Biosynthesis(4), Microbial bioremediation and biosurfactants(4), Enzyme Structure and Function(4)

Publications24 total

Data from BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in <i>BRAF</i>-Mutated Colorectal Cancers
2023Open Access
Data from BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in <i>BRAF</i>-Mutated Colorectal Cancers
2023Open Access
Abstract 4260: 3D colorectal cancer organoids as preclinical models for assessment of activity of RAF inhibitor BGB-283
Cancer Research·2016· 1 cited
Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis
Bioorganic & Medicinal Chemistry Letters·2016· 7 citedOpen Access
Abstract 2589: Investigations of covalent binding efficiency for third-generation EGFR irreversible inhibitors AZD9291 and CO-1686
Cancer Research·2015· 1 cited
Abstract 3706: Oncogenic RAF mutants that signal as functional dimers are resistant to current RAF inhibitors but sensitive to a novel inhibitor of RAF dimer kinase activity
Cancer Research·2014
Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3-kinase and the mammalian target of rapamycin (mTOR)
Molecular Cancer Therapeutics·2009· 1 cited
Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)
Molecular Cancer Therapeutics·2009· 4 cited
A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A), demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro
2007· 7 cited
A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer
2006· 12 cited
Raman evidence for product binding to the enzyme W137F 4‐chlorobenzoyl‐CoA dehalogenase in two conformational states
Journal of Raman Spectroscopy·2005· 2 cited
The Strength of Dehalogenase−Substrate Hydrogen Bonding Correlates with the Rate of Meisenheimer Intermediate Formation
Biochemistry·2003· 19 cited
Online capillary LC-FTMS for the analysis of covalent enzyme intermediates of polyketide and nonribosomal peptide synthetases
2002
Timing of Epimerization and Condensation Reactions in Nonribosomal Peptide Assembly Lines:  Kinetic Analysis of Phenylalanine Activating Elongation Modules of Tyrocidine Synthetase B
Biochemistry·2002· 85 cited
Raman Evidence for Meisenheimer Complex Formation in the Hydrolysis Reactions of 4-Fluorobenzoyl- and 4-Nitrobenzoyl-Coenzyme A Catalyzed by 4-Chlorobenzoyl-Coenzyme A Dehalogenase
Biochemistry·2002· 25 cited
Yersiniabactin Synthetase
Chemistry & Biology·2002· 181 citedOpen Access
Determination of the Chlorine Kinetic Isotope Effect on the 4-Chlorobenzoyl-CoA Dehalogenase-Catalyzed Nucleophilic Aromatic Substitution
Archives of Biochemistry and Biophysics·2002· 11 cited
Role of Active Site Binding Interactions in 4-Chlorobenzoyl-Coenzyme A Dehalogenase Catalysis
Biochemistry·2001· 38 cited
Substrate Recognition and Selection by the Initiation Module PheATE of Gramicidin S Synthetase
Journal of the American Chemical Society·2001· 52 cited
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
Current Opinion in Chemical Biology·2001· 297 cited
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Frequent Co-authors

Debra Dunaway‐Mariano(8), Christopher T. Walsh(6), Jian Dong(5), Paul Carey(5), Steven D. Knight(4), Deborah A. Miller(3), Xiang Hong(3), Yansheng Wei(3), David Sutton(3), Melody Diamond(3), Changyou Zhou(3), Chiu-Mei Sung(3), Dashyant Dhanak(3), Lianhai Zhang(3), Jiafu Ji(3), Yunguang Du(3), Thomas A. Keating(2), Kimberly L. Taylor(2), Xuefeng Lü(2), Jeffrey R. Jackson(2)