Helen H. Evans

Novartis (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.2kcitations96works1.02yr avg
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Research Topics

DNA Repair Mechanisms(34), Carcinogens and Genotoxicity Assessment(31), Radiation Therapy and Dosimetry(16), Effects of Radiation Exposure(16), Photodynamic Therapy Research Studies(15)

Publications96 total

Abstract CT073: A first-in-human study of oral TNO155 (batoprotafib) alone and in combination with EGF816 (nazartinib) in adult patients with advanced solid tumors
Cancer Research·2025· 1 cited
Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors
Journal for ImmunoTherapy of Cancer·2023· 33 citedOpen Access
Initial Evidence for the Efficacy of Naporafenib in Combination With Trametinib in <i>NRAS</i>-Mutant Melanoma: Results From the Expansion Arm of a Phase Ib, Open-Label Study
Journal of Clinical Oncology·2023· 47 citedOpen Access
Phase I dose-finding study of oral ERK1/2 inhibitor LTT462 in patients (pts) with advanced solid tumors harboring MAPK pathway alterations.
Journal of Clinical Oncology·2020· 32 cited
Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with<i>RAS/RAF</i>Alterations
The Oncologist·2019· 85 citedOpen Access
In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus.
PubMed·2012· 1 citedOpen Access
<i>In Vitro</i> Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus
Human Gene Therapy·2011· 10 cited
Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems?
Human Gene Therapy·2009· 10 cited
Human prostate stem cells support replication of a prostate-targeted, conditionally replicating adenovirus
Human Gene Therapy·2009
The TP53 Dependence of Radiation-Induced Chromosome Instability in Human Lymphoblastoid Cells
Radiation Research·2003· 30 cited
Induction of Genomic Instability in TK6 Human Lymphoblasts Exposed to<sup>137</sup>Cs γ Radiation: Comparison to the Induction by Exposure to Accelerated<sup>56</sup>Fe Particles
Radiation Research·2003· 17 cited
Characteristics of Genomic Instability in Clones of TK6 Human Lymphoblasts Surviving Exposure to<sup>56</sup>Fe Ions
Radiation Research·2002· 12 cited
IN MEMORIAM
Radiation Research·2002
Antimutagenicity of WR-1065 in L5178Y Cells Exposed to Accelerated<sup>56</sup>Fe Ions
Radiation Research·2002· 7 cited
Cells From Different Regions of the Intervertebral Disc
Spine·2002· 177 cited
Characteristics of chromosome instability in the human lymphoblast cell line WTK1
Cancer Genetics and Cytogenetics·2001· 11 cited
Diverse Delayed Effects in Human Lymphoblastoid Cells Surviving Exposure to High-LET<sup>56</sup>Fe Particles or Low-LET<sup>137</sup>Cs Gamma Radiation
Radiation Research·2001· 13 cited
Genotoxic Effects of High-Energy Iron Particles in Human Lymphoblasts Differing in Radiation Sensitivity
Radiation Research·2001· 16 cited
Phthalocyanine 4 photodynamic therapy-induced apoptosis of mouse L5178Y-R cells results from a delayed but extensive release of cytochrome c from mitochondria
Cancer Letters·2001· 43 cited
TP53‐dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase‐positive cell lines
Genes Chromosomes and Cancer·2001· 2 cited
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Frequent Co-authors

J. Mencl(12), Min‐Fen Horng(12), Marlene Ricanati(11), Nancy L. Oleinick(10), Thomas E. Evans(6), Marian E. Clay(5), T. E. Hui(5), G. Bakale(4), Janusz Z. Beer(4), Jeffrey L. Schwartz(4), Robert Jordan(4), Antonio R. Antunez(3), M F Horng(3), R. F. Jostes(3), F.T. Cross(3), Robert W. Atcher(3), David M. DeMarini(2), Filip Jankú(2), Martin Schüler(2), Daniel Shao-Weng Tan(2)